Opana ER Side Effects
Generic name: oxymorphone
Note: This document contains side effect information about oxymorphone. Some of the dosage forms listed on this page may not apply to the brand name Opana ER.
Some side effects of Opana ER may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to oxymorphone: oral tablet, oral tablet extended release
Get emergency medical help if you have any of these signs of an allergic reaction while taking oxymorphone (the active ingredient contained in Opana ER) hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
fever, chills, cough with yellow or green mucus;
stabbing chest pain, wheezing, feeling short of breath; or
Common side effects may include:
dry mouth, nausea, loss of appetite;
stomach pain, constipation, diarrhea;
dizziness, drowsiness, headache, tired feeling;
sleep problems (insomnia); or
mild rash or itching.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to oxymorphone: injectable solution, oral tablet, oral tablet extended release, rectal suppository
Nervous system side effects have included drowsiness, sedation, lightheadedness, unusual tiredness, weakness, headache, dysphoria, dizziness, mental impairment, CNS depression, euphoria, miosis, diplopia, blurred vision, nervousness, restlessness, confusion, mental clouding, trouble sleeping, paradoxical CNS stimulation, hallucinations, and mental depression.
Gastrointestinal side effects have included nausea, vomiting, dry mouth, constipation, biliary tract spasm, cramps or pain, loss of appetite, paralytic ileus, and toxic megacolon in patients with inflammatory bowel disease.
Cardiovascular side effects have included hypotension, orthostatic hypotension (particularly in ambulatory patients), tachycardia, bradycardia, palpitations, and flushing.
Respiratory side effects have included respiratory depression, atelectasis, allergic bronchospastic reaction, allergic laryngeal edema, apnea and allergic laryngospasm.
Genitourinary side effects have included ureteral spasm, urinary retention or hesitancy, and antidiuretic effect.
Dermatologic side effects have included sweating.
Hypersensitivity side effects have included allergic dermatitis, urticaria, skin rash, hives and/or itching, and swelling of the face.
Other side effects have included tolerance, psychological dependence, and physical dependence.
Ocular side effects including miosis, diplopia, and blurred vision have been reported.
General side effects including fatigue and asthenia have been reported.
Local side effects including injection site reactions have been reported with the use of oxymorphone (the active ingredient contained in Opana ER) injection.
Hepatic side effects including biliary colic have been reported.
Renal side effects including ureteral spasm, urinary hesitation, urinary retention, and oliguria have been reported.
More Opana ER resources
- Opana ER Prescribing Information (FDA)
- Opana ER extended-release tablets MedFacts Consumer Leaflet (Wolters Kluwer)
- Opana ER Advanced Consumer (Micromedex) - Includes Dosage Information
- Oxymorphone Prescribing Information (FDA)
- Opana MedFacts Consumer Leaflet (Wolters Kluwer)
- Opana Prescribing Information (FDA)
- Opana Monograph (AHFS DI)
- Opana Consumer Overview
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