Omontys Side Effects
Generic name: peginesatide
Medically reviewed by Drugs.com. Last updated on Jan 25, 2024.
Note: This document contains side effect information about peginesatide. Some dosage forms listed on this page may not apply to the brand name Omontys.
Applies to peginesatide: injectable solution.
Warning
You should not use this medication if you are allergic to peginesatide, or if you have untreated or uncontrolled high blood pressure.
Before using peginesatide, tell your doctor if you have heart disease, congestive heart failure, high blood pressure, cancer, a seizure disorder, a blood cell or clotting disorder (such as sickle cell anemia or hemophilia), or a history of stroke, heart attack, or blood clot.
Your other medication doses may need to be changed after you start using peginesatide. Tell your doctor about all medications you use.
To be sure this medication is helping your condition, your iron and blood cells will need to be checked with frequent blood tests. Your blood pressure will also need to be checked often. Visit your doctor regularly.
Contact your doctor if you feel weak, lightheaded, or short of breath, or if your skin looks pale. These may be signs that your body has stopped responding to this medication.
Peginesatide can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use peginesatide.
Seek emergency medical help if you have symptoms of heart or circulation problems, such as: chest pain, sudden numbness or weakness, severe headache, problems with vision or speech, sudden cough, coughing up blood, pain or warmth in your leg, cold or tingly feeling, feeling short of breath, rapid weight gain, or problems with your hemodialysis vein access.
Get emergency medical help if you have any of these signs of an allergic reaction while taking peginesatide (the active ingredient contained in Omontys) hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Contact your doctor if you feel weak, lightheaded, or short of breath, or if your skin looks pale. These may be signs that your body has stopped responding to this medication.
Peginesatide can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use peginesatide. Seek emergency medical help if you have symptoms of heart or circulation problems, such as:
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chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
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sudden numbness or weakness, especially on one side of the body;
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sudden severe headache, confusion, problems with vision, speech, or balance;
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chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
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pain, swelling, warmth, or redness in one or both legs;
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numbness, tingling, cold feeling, or pale appearance in your arms or legs;
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feeling short of breath, even with mild exertion;
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swelling, rapid weight gain;
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feeling light-headed, fainting; or
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if your hemodialysis vein access stops working.
Call your doctor at once if you have any other serious side effect such as:
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easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
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feeling light-headed, fainting;
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pale skin, feeling short of breath, rapid heart rate, trouble concentrating;
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high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling);
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fever;
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seizure (convulsions); or
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dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
Less serious side effects of peginesatide may include:
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cough;
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headache;
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back pain, muscle spasm, pain in your arms or legs;
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joint pain; or
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cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to peginesatide: injectable solution.
Cardiovascular
Cardiovascular side effects have included hypotension (14.2%), hypertension (13.2%), and procedural hypotension (10.9%).[Ref]
Gastrointestinal
Gastrointestinal side effects have included diarrhea (18.4%), nausea (17.4%), and vomiting (15.3%).[Ref]
General
General side effects have included pyrexia (12.2%).[Ref]
Immunologic
Immunologic side effects have included the development of peginesatide (the active ingredient contained in Omontys) specific antibodies (1.2%).[Ref]
Metabolic
Metabolic side effects have included hyperkalemia (11.4%).[Ref]
Musculoskeletal
Musculoskeletal side effects have included muscle spasms (15.3%), pain in extremity (10.9%), back pain (10.9%), and arthralgia (10.7%).[Ref]
Nervous system
Nervous system side effects have included headache (15.4%).[Ref]
Other
Other side effects have included arteriovenous fistula site complication (16.1%).[Ref]
Respiratory
Respiratory side effects have included dyspnea (18.4%), cough (15.9%), and upper respiratory infection (11.0%).[Ref]
Hypersensitivity
Hypersensitivity side effects have included postmarketing reports of serious allergic reactions including fatal reactions (0.02%).
More about Omontys (peginesatide)
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: recombinant human erythropoietins
- Breastfeeding
Patient resources
Related treatment guides
References
1. Product Information. Omontys (peginesatide). Takeda Pharmaceuticals America. 2012.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
