Skip to Content

Ocufen Side Effects

Generic Name: flurbiprofen ophthalmic

Note: This page contains side effects data for the generic drug flurbiprofen ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Ocufen.

For the Consumer

Applies to flurbiprofen ophthalmic: ophthalmic solution

As well as its needed effects, flurbiprofen ophthalmic (the active ingredient contained in Ocufen) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking flurbiprofen ophthalmic, check with your doctor immediately:

Incidence not known
  • Eye irritation or redness
  • increased sensitivity of the eyes to light
  • red or bloodshot eye

Some flurbiprofen ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known
  • Stinging or burning of the eye when medicine is applied

For Healthcare Professionals

Applies to flurbiprofen ophthalmic: ophthalmic solution


Ocular side effects have included transient burning, discomfort, or stinging upon instillation in approximately 15% of patients. Local itching or foreign body sensation, fibrosis, miosis, mydriasis, tearing, hyphema, ocular hyperemia, dull pain, photophobia, follicular conjunctivitis, and increased bleeding tendency of ocular tissues with ocular surgery have also been reported. Topical flurbiprofen may slow corneal wound healing. Some data indicate slightly greater postoperative intraocular pressures associated with flurbiprofen relative to placebo.[Ref]


1. "Product Information. Ocufen Liquifilm (flurbiprofen)." Allergan Inc, Irvine, CA.

2. Hersh PS, Rice BA, Baer JC, Wells PA, Lynch SE, McGuigan LJ, Foster CS "Topical nonsteroidal agents and corneal wound healing." Arch Ophthalmol 108 (1990): 577-83

3. Tsuchisaka H, Takase M "Topical flurbiprofen in intraocular surgery on diabetic and nondiabetic patients." Ann Ophthalmol 22 (1990): 15-9,23

4. Lyons CJ, Hakin KN, Watson PG "Topical flurbiprofen: an effective treatment for episcleritis?" Eye 4(Pt 3) (1990): 521-5

It is possible that some side effects of Ocufen may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.