Numorphan Side Effects

Generic name: oxymorphone

Note: This document contains side effect information about oxymorphone. Some of the dosage forms listed on this page may not apply to the brand name Numorphan.

Some side effects of Numorphan may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to oxymorphone: oral tablet, oral tablet extended release

Get emergency medical help if you have any of these signs of an allergic reaction while taking oxymorphone (the active ingredient contained in Numorphan) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• a light-headed feeling, like you might pass out;

• seizure (convulsions);

• fever, chills, cough with yellow or green mucus;

• stabbing chest pain, wheezing, feeling short of breath; or

• severe vomiting.

Common side effects may include:

• dry mouth, nausea, loss of appetite;

• stomach pain, constipation, diarrhea;

• dizziness, drowsiness, headache, tired feeling;

• increased sweating;

• sleep problems (insomnia); or

• mild rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to oxymorphone: injectable solution, oral tablet, oral tablet extended release, rectal suppository

Nervous system

Nervous system side effects have included drowsiness, sedation, lightheadedness, unusual tiredness, weakness, headache, dysphoria, dizziness, mental impairment, CNS depression, euphoria, miosis, diplopia, blurred vision, nervousness, restlessness, confusion, mental clouding, trouble sleeping, paradoxical CNS stimulation, hallucinations, and mental depression.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, dry mouth, constipation, biliary tract spasm, cramps or pain, loss of appetite, paralytic ileus, and toxic megacolon in patients with inflammatory bowel disease.

Cardiovascular

Cardiovascular side effects have included hypotension, orthostatic hypotension (particularly in ambulatory patients), tachycardia, bradycardia, palpitations, and flushing.

Respiratory

Respiratory side effects have included respiratory depression, atelectasis, allergic bronchospastic reaction, allergic laryngeal edema, apnea and allergic laryngospasm.

Genitourinary

Genitourinary side effects have included ureteral spasm, urinary retention or hesitancy, and antidiuretic effect.

Dermatologic

Dermatologic side effects have included sweating.

Hypersensitivity

Hypersensitivity side effects have included allergic dermatitis, urticaria, skin rash, hives and/or itching, and swelling of the face.

Other

Other side effects have included tolerance, psychological dependence, and physical dependence.

Ocular

Ocular side effects including miosis, diplopia, and blurred vision have been reported.

General

General side effects including fatigue and asthenia have been reported.

Local

Local side effects including injection site reactions have been reported with the use of oxymorphone (the active ingredient contained in Numorphan) injection.

Hepatic

Hepatic side effects including biliary colic have been reported.

Renal

Renal side effects including ureteral spasm, urinary hesitation, urinary retention, and oliguria have been reported.

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