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Nubain Side Effects

Generic Name: nalbuphine

Note: This page contains side effects data for the generic drug nalbuphine. It is possible that some of the dosage forms included below may not apply to the brand name Nubain.

It is possible that some side effects of Nubain may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to nalbuphine: injection solution

As well as its needed effects, nalbuphine (the active ingredient contained in Nubain) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking nalbuphine, check with your doctor or nurse immediately:

Rare
  • Chest pain or discomfort
  • difficult or labored breathing
  • difficulty swallowing
  • fainting
  • false beliefs that cannot be changed by facts
  • fast, pounding, or irregular heartbeat or pulse
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • redness of the face, neck, arms and occasionally, upper chest
  • seeing, hearing, or feeling things that are not there
  • sense of detachment from self or body
  • shortness of breath
  • slow or irregular heartbeat
  • wheezing
Incidence not known
  • Blue lips and fingernails
  • convulsions
  • coughing that sometimes produces a pink frothy sputum
  • decrease in consciousness
  • difficult, fast, or noisy breathing, sometimes with wheezing
  • fear or nervousness
  • fever
  • hyperventilation
  • increased sweating
  • loss of bladder control
  • muscle spasm or jerking of all extremities
  • pale skin
  • shakiness in legs, arms, hands, or feet
  • sleepiness or unusual drowsiness
  • stomach pain
  • sudden loss of consciousness
  • swelling in legs and ankles
  • trembling or shaking of hands or feet

Some nalbuphine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Dizziness or lightheadedness
  • drowsiness
  • feeling of constant movement of self or surroundings
  • nausea
  • relaxed and calm
  • sensation of spinning
  • sleepiness
  • sweaty, clammy skin
  • vomiting
Less common
  • Dry mouth
  • Headache
Rare
  • Acid or sour stomach
  • aggressive or angry
  • belching
  • blurred vision
  • burning
  • changes in speech
  • confusion
  • cough
  • discouragement
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • dysphoria
  • excessive crying
  • false or unusual sense of well-being
  • feeling of heaviness
  • feeling of warmth
  • feeling sad or empty
  • floating feeling
  • frequent strong or increased urge to urinate
  • headache
  • heartburn
  • hives or welts
  • indigestion
  • irritability
  • itching of skin
  • lack of appetite
  • loss of interest or pleasure
  • nervousness
  • numbness
  • pounding in the ears
  • restlessness
  • skin rash
  • slow or fast heartbeat
  • stomach discomfort, upset, or pain
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • tingling feeling of unreality
  • unusual tiredness or weakness
Incidence not known
  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at site

For Healthcare Professionals

Applies to nalbuphine: compounding powder, injectable solution

Nervous system

Nervous system side effects have frequently included sedation (36%), dizziness/vertigo (5%), and headache (3%). Nervousness, depression, restlessness, crying, euphoria, floating, hostility, unusual dreams, confusion, faintness, hallucinations, dysphoria, feeling of heaviness, numbness, tingling, and unreality have been reported in less than 1% of patients. A depressed level of consciousness, somnolence, tremor, anxiety, agitation. and seizures have also been reported.

Cardiovascular

Cardiovascular side effects have included hypertension, hypotension, bradycardia, and tachycardia.

Gastrointestinal

Gastrointestinal side effects have frequently included nausea/vomiting (6%) and dry mouth (4%). Cramps, dyspepsia, and bitter taste have been reported in less than 1% of patients.

Respiratory

Respiratory side effects have included respiratory depression, dyspnea, asthma, and pulmonary edema.

Dermatologic

Dermatologic side effects have included itching, burning, and urticaria.

Other

Other side effects have frequently included a sweaty/clammy feeling (9%). Speech difficulty and flushing/warmth have been reported in less than 1% of patients.

Genitourinary

Genitourinary side effects have included urinary urgency.

Ocular

Ocular side effects have included blurred vision.

Hypersensitivity

Hypersensitivity reactions have included anaphylactic/anaphylactoid reactions including shock, respiratory distress, respiratory arrest, bradycardia, cardiac arrest, hypotension, and laryngeal edema. Some of these allergic reactions may be life-threatening. Death has been reported following severe allergic reactions to nalbuphine (the active ingredient contained in Nubain) Stridor, bronchospasm, wheezing, edema, rash, pruritus, nausea, vomiting, diaphoresis, weakness, and shakiness have also been reported.

Local

Local side effects have included pain, swelling, redness, burning, and hot sensations at the site of injection.

General

General side effects including abdominal pain and pyrexia have been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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