NovoSeven RT Side Effects

Generic Name: coagulation factor viia

Note: This page contains side effects data for the generic drug coagulation factor viia. It is possible that some of the dosage forms included below may not apply to the brand name NovoSeven RT.

It is possible that some side effects of NovoSeven RT may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to coagulation factor viia: intravenous powder for solution

Along with its needed effects, coagulation factor viia (the active ingredient contained in NovoSeven RT) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking coagulation factor viia:

More common
  • Bleeding problems
  • fever
  • high blood pressure
  • joint or muscle pain and/or stiffness
Less common or rare
  • Bloating or swelling of the face, hands, lower legs, and/or feet
  • bluish color of the hands or feet
  • blurred vision
  • changes in facial color
  • chest pain
  • chills
  • cold sweats
  • confusion
  • continuing thirst
  • cough
  • dizziness
  • excessive sweating
  • faintness
  • fast heartbeat
  • hives and/or itching
  • large flat blue or purplish patches on the skin
  • lightheadedness when getting up from a lying or sitting position suddenly
  • persistent bleeding or oozing from puncture sites or mucous membranes (bowel, mouth, nose, or urinary bladder)
  • puffiness or swelling of the eyelids or around the eyes
  • shakiness
  • shortness of breath
  • skin rash
  • slow or irregular heartbeat (less than 50 beats per minute)
  • slurred speech
  • sneezing
  • sore throat
  • sudden decrease in the amount of urine
  • swelling of the face, fingers, feet, and/or lower legs
  • troubled breathing, tightness in the chest, and/or wheezing
  • unusual tiredness or weakness
  • weight gain (unusual)

Some side effects of coagulation factor viia may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare
  • Burning or stinging at the injection site
  • changes in the blood pressure or pulse rate
  • drowsiness
  • flushing (redness of the face)
  • headache
  • nausea or vomiting
  • pinpoint red or purple spots on the skin

For Healthcare Professionals

Applies to coagulation factor viia: intravenous powder for injection


Hematologic side effects have included hemorrhage, decreased plasma fibrogen, coagulation disorders, increased fibrinolysis, decreased prothrombin, disseminated intravascular coagulation, thrombophlebitis, arterial thrombosis, and deep vein thrombosis.


Cardiovascular side effects have included edema, hypertension, hypotension, myocardial infarction, angina pectoris, and bradycardia.


General side effects have included pain and fever.

Nervous system

Nervous system side effects have included headache, intracranial hemorrhage, cerebral infarction, cerebral ischemia, and subdural hematoma.


Hypersensitivity side effects have included isolated cases of hypersensitivity reactions including anaphylactic reactions.


Respiratory side effects have included pulmonary embolism and pneumonia.


Local side effects have included injection site reaction.


Gastrointestinal side effects have included nausea and vomiting.


Dermatologic side effects have included rash, pruritus, and purpura.


Musculoskeletal side effects have included arthralgia and hemarthrosis.


Renal side effects have included abnormal renal function.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.