Novolin 70 / 30 Side Effects
Generic Name: insulin isophane / insulin regular
Note: This page contains side effects data for the generic drug insulin isophane / insulin regular. It is possible that some of the dosage forms included below may not apply to the brand name Novolin 70 / 30.
It is possible that some side effects of Novolin 70 / 30 may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to insulin isophane / insulin regular: pens, vials
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking insulin isophane / insulin regular:
Redness, swelling, itching, or mild pain at the injection site.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; wheezing; muscle pain); change in skin to thick or thin where the injection was given; changes in vision; chills; confusion; dizziness; drowsiness; fainting; fast or irregular heartbeat; headache; loss of consciousness; mood changes; seizures; shortness of breath; slurred speech; swelling of the hands, ankles, or feet; tremor; trouble breathing; trouble concentrating; unusual hunger; unusual sweating; weakness.
For Healthcare Professionals
Applies to insulin isophane / insulin regular: subcutaneous suspension
Adverse reactions observed with insulin therapy include hypoglycemia, allergic reactions, local injection site reactions, lipodystrophy, rash, pruritus, weight gain, and edema.[Ref]
Hypersensitivity side effects have included both local and systemic reactions. Local reactions have presented as erythema, swelling, heat, or subcutaneous nodules. They usually occurred within the first two weeks of therapy and then disappear. Systemic allergy is a generalized allergy to insulin which may present as a rash over the whole body, shortness of breath, wheezing, drop in blood pressure, fast pulse, or sweating. Severe cases may be life-threatening.
There have been rare reports of patients with hypersensitivity reactions to human insulins who have tolerated insulins of animal origin.[Ref]
Uncommon (0.1% to 1%): Local reactions such as redness, swelling, or itching at the injection site
Very rare (less than 0.01%): Systemic reactions[Ref]
Frequency not reported: Peripheral edema[Ref]
Insulin may cause sodium retention and edema, especially if previously poor metabolic control is improved by intensified insulin therapy.[Ref]
Uncommon (0.1% to 1%): Lipodystrophy
Frequency not reported: Rash, pruritus[Ref]
Very common (10% or more): Hypoglycemia[Ref]
Refraction anomalies may occur upon initiation of insulin; symptoms are usually transient. Intensification of insulin therapy may be associated with temporary worsening of diabetic retinopathy.[Ref]
Frequency not reported: Refraction anomalies, temporary worsening of diabetic retinopathy[Ref]
Injection site reactions including pain, redness, hives, inflammation, bruising, swelling, and itching, may occur. These reactions are usually transitory and may be related to factors other than insulin, such as irritants in the skin cleansing agent or poor injection technique.[Ref]
Frequency not reported: Injection site reactions[Ref]
Frequency not reported: Weight gain[Ref]
Weight gain has been attributed to the anabolic effects of insulin and the decrease in glycosuria.[Ref]
Frequency not reported: Anti-insulin antibodies[Ref]
Frequency not reported: Acute painful neuropathy[Ref]
Fast improvement in blood glucose has been associated with acute painful neuropathy, which is generally reversible.[Ref]
1. Cerner Multum, Inc. "Australian Product Information." O 0
2. "Product Information. Humulin 70/30 (insulin isophane-insulin regular)." Lilly, Eli and Company, Indianapolis, IN.
3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
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