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Novolin 70 / 30 Side Effects

Generic Name: insulin isophane / insulin regular

Note: This page contains side effects data for the generic drug insulin isophane / insulin regular. It is possible that some of the dosage forms included below may not apply to the brand name Novolin 70 / 30.

It is possible that some side effects of Novolin 70 / 30 may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to insulin isophane / insulin regular: pens, vials

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Redness, swelling, itching, or mild pain at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur while taking insulin isophane / insulin regular:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; wheezing; muscle pain); change in skin to thick or thin where the injection was given; changes in vision; chills; confusion; dizziness; drowsiness; fainting; fast or irregular heartbeat; headache; loss of consciousness; mood changes; seizures; shortness of breath; slurred speech; swelling of the hands, ankles, or feet; tremor; trouble breathing; trouble concentrating; unusual hunger; unusual sweating; weakness.

For Healthcare Professionals

Applies to insulin isophane / insulin regular: subcutaneous suspension


Adverse reactions observed with insulin therapy include hypoglycemia, allergic reactions, local injection site reactions, lipodystrophy, rash, pruritus, weight gain, and edema.[Ref]


Hypersensitivity side effects have included both local and systemic reactions. Local reactions have presented as erythema, swelling, heat, or subcutaneous nodules. They usually occurred within the first two weeks of therapy and then disappear. Systemic allergy is a generalized allergy to insulin which may present as a rash over the whole body, shortness of breath, wheezing, drop in blood pressure, fast pulse, or sweating. Severe cases may be life-threatening.

There have been rare reports of patients with hypersensitivity reactions to human insulins who have tolerated insulins of animal origin.[Ref]

Uncommon (0.1% to 1%): Local reactions such as redness, swelling, or itching at the injection site
Very rare (less than 0.01%): Systemic reactions[Ref]


Frequency not reported: Peripheral edema[Ref]

Insulin may cause sodium retention and edema, especially if previously poor metabolic control is improved by intensified insulin therapy.[Ref]


Uncommon (0.1% to 1%): Lipodystrophy
Frequency not reported: Rash, pruritus[Ref]


Very common (10% or more): Hypoglycemia[Ref]


Refraction anomalies may occur upon initiation of insulin; symptoms are usually transient. Intensification of insulin therapy may be associated with temporary worsening of diabetic retinopathy.[Ref]

Frequency not reported: Refraction anomalies, temporary worsening of diabetic retinopathy[Ref]


Injection site reactions including pain, redness, hives, inflammation, bruising, swelling, and itching, may occur. These reactions are usually transitory and may be related to factors other than insulin, such as irritants in the skin cleansing agent or poor injection technique.[Ref]

Frequency not reported: Injection site reactions[Ref]


Frequency not reported: Weight gain[Ref]

Weight gain has been attributed to the anabolic effects of insulin and the decrease in glycosuria.[Ref]


Frequency not reported: Anti-insulin antibodies[Ref]

Nervous system

Frequency not reported: Acute painful neuropathy[Ref]

Fast improvement in blood glucose has been associated with acute painful neuropathy, which is generally reversible.[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Humulin 70/30 (insulin isophane-insulin regular)." Lilly, Eli and Company, Indianapolis, IN.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.