Neurontin Side Effects
Generic name: gabapentin
Note: This document contains side effect information about gabapentin. Some of the dosage forms listed on this page may not apply to the brand name Neurontin.
Some side effects of Neurontin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to gabapentin: oral capsule, oral solution, oral suspension, oral tablet
Along with its needed effects, gabapentin (the active ingredient contained in Neurontin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking gabapentin:More common
- Clumsiness or unsteadiness
- continuous, uncontrolled, back-and-forth, or rolling eye movements
- Aggressive behavior or other behavior problems
- concentration problems and change in school performance
- false sense of well-being
- hyperactivity or increase in body movements
- rapidly changing moods
- reacting too quickly, too emotional, or overreacting
- suspiciousness or distrust
- Black, tarry stools
- chest pain
- depression, irritability, or other mood or mental changes
- loss of memory
- pain or swelling in the arms or legs
- painful or difficult urination
- shortness of breath
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- Abdominal or stomach pain
- blistering, peeling, or loosening of the skin
- clay-colored stools
- dark urine
- decreased urine output
- fast or irregular heartbeat
- increased thirst
- joint pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- muscle ache or pain
- red skin lesions, often with a purple center
- red, irritated eyes
- skin rash
- unpleasant breath odor
- vomiting of blood
- yellow eyes or skin
Some side effects of gabapentin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Blurred vision
- cold or flu-like symptoms
- lack or loss of strength
- lower back or side pain
- swelling of the hands, feet, or lower legs
- trembling or shaking
- Accidental injury
- appetite increased
- back pain
- bloated or full feeling
- body aches or pain
- burning, dry, or itching eyes
- change in vision
- change in walking and balance
- clumsiness or unsteadiness
- cough producing mucus
- decrease in sexual desire or ability
- difficulty with breathing
- dryness of the mouth or throat
- excess air or gas in the stomach or intestines
- excessive tearing
- eye discharge
- feeling faint, dizzy, or lightheadedness
- feeling of warmth or heat
- flushed, dry skin
- flushing or redness of the skin, especially on the face and neck
- frequent urination
- fruit-like breath odor
- impaired vision
- increased hunger
- increased sensitivity to pain
- increased sensitivity to touch
- increased thirst
- low blood pressure
- noise in the ears
- pain, redness, rash, swelling, or bleeding where the skin is rubbed off
- passing gas
- redness or swelling in the ear
- redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
- runny nose
- tender, swollen glands in the neck
- tightness in the chest
- tingling in the hands and feet
- troubled breathing
- trouble with sleeping
- trouble with swallowing
- trouble with thinking
- unexplained weight loss
- voice changes
- weakness or loss of strength
- weight gain
For Healthcare Professionals
Applies to gabapentin: compounding powder, oral capsule, oral solution, oral tablet, oral tablet extended release
Nervous system side effects have been common. Somnolence, dizziness, ataxia, headache, and fatigue have been reported to occur in more than 10% of treated patients. Vertigo, hyperkinesia, paresthesia, decreased or absent reflexes, increased reflexes, anxiety, and hostility have been reported frequently. CNS tumors, syncope, dreaming abnormal, aphasia, hypesthesia, intracranial hemorrhage, hypotonia, dysesthesia, paresis, dystonia, hemiplegia, facial paralysis, stupor, cerebellar dysfunction, positive Babinski sign, decreased position sense, subdural hematoma, apathy, hallucination, decrease or loss of libido, agitation, paranoia, depersonalization, euphoria, feeling high, doped-up sensation, suicide attempt, and psychosis have been reported infrequently. Choreoathetosis, orofacial dyskinesia, encephalopathy, nerve palsy, personality disorder, increased libido, subdued temperament, apraxia, fine motor control disorder, meningismus, local myoclonus, hyperesthesia, hypokinesia, mania, neurosis, hysteria, antisocial reaction, and suicide have been reported rarely. Nystagmus, tremor, nervousness, amnesia, dysarthria and depression have also been reported. A small number of cases of absence status and status epilepticus have occurred in patients taking gabapentin (the active ingredient contained in Neurontin) Cases of delirium tremens have been reported upon gabapentin withdrawal.
Gastrointestinal side effects have been reported in one to three percent of treated patients. Anorexia, flatulence, and gingivitis have been reported frequently. Glossitis, gum hemorrhage, thirst, stomatitis, increased salivation, gastroenteritis, hemorrhoids, bloody stools, and fecal incontinence have been reported infrequently. Dysphagia, eructation, pancreatitis, peptic ulcer, colitis, blisters in mouth, tooth discoloration, salivary gland enlarged, lip hemorrhage, esophagitis, hiatal hernia, hematemesis, proctitis, irritable bowel syndrome, rectal hemorrhage, and esophageal spasm have been reported rarely. Dyspepsia, dry mouth, constipation, dental abnormalities, flatulence, increased appetite, breast enlargement, and weight gain have also been reported.
Other side effects have been reported to include withdrawal effects. Withdrawal of gabapentin (the active ingredient contained in Neurontin) therapy has been reported to cause the following effects in less than 2% of treated patients: somnolence, ataxia, fatigue, nausea, vomiting, and dizziness.
Hearing loss, earache, tinnitus, inner ear infection, otitis, taste loss, unusual taste, ear fullness, perforated ear drum, sensitivity to noise, eustachian tube dysfunction, otitis externa, odd smell, and labyrinthitis have also been reported.
Other side effects reported postmarketing have included angioedema, blood glucose fluctuation, breast enlargement, elevated creatine kinase, elevated liver function tests, erythema multiforme, fever, hyponatremia, jaundice, movement disorder, and Stevens-Johnson syndrome.
The patients reported to have decreased white blood cell counts were also taking carbamazepine.
Hematologic side effects have frequently been reported to include purpura. Anemia, thrombocytopenia, and lymphadenopathy have been reported infrequently. Increased WBC count, lymphocytosis, non-Hodgkin's lymphoma, and increased bleeding time have been reported rarely. Isolated cases of decreased white blood cell counts have also been reported.
Cardiovascular side effects including hypertension have been reported to occur in more than one percent of patients taking gabapentin (the active ingredient contained in Neurontin) Hypotension, angina pectoris, peripheral vascular disorder, palpitation, tachycardia, and murmur have been reported infrequently. Atrial fibrillation, heart failure, thrombophlebitis, deep thrombophlebitis, myocardial infarction, cerebrovascular accident, pulmonary thrombosis, ventricular extrasystoles, bradycardia, premature atrial contraction, pericardial rub, heart block, pulmonary embolus, hyperlipidemia, hypercholesterolemia, pericardial effusion, and pericarditis have been reported rarely. A case of gabapentin induced edema has also been reported.
Ocular side effects including abnormal vision have been reported frequently. Cataract, conjunctivitis, dry eyes, eye pain, visual field defect, photophobia, bilateral or unilateral ptosis, eye hemorrhage, hordeolum, eye twitching, diplopia and blurred vision have been reported infrequently. Eye itching, abnormal accommodation, eye focusing problem, watery eyes, retinopathy, glaucoma, iritis, corneal disorders, lacrimal dysfunction, degenerative eye changes, blindness, retinal degeneration, miosis, chorioretinitis, and strabismus have been reported rarely. A case of oculogyric crisis has also been reported.
Psychiatric side effects including two cases of intolerable aggressive behavior have been reported. One case of hypomania has also been reported.
Dermatologic side effects including alopecia, eczema, dry skin, increased sweating, urticaria, hirsutism, seborrhea, cyst, and herpes simplex have been reported infrequently. Herpes zoster, skin discolor, skin papules, photosensitive reaction, leg ulcer, scalp seborrhea, psoriasis, desquamation, maceration, skin nodules, subcutaneous nodule, melanosis, skin necrosis, and local swelling have been reported rarely. One case of alopecia and one case of leukocytoclastic vasculitis have been reported.
Hypersensitivity side effects including a case of hypersensitivity syndrome have been reported.
Genitourinary side effects including hematuria, dysuria, urination frequency, cystitis, urinary retention, urinary incontinence, vaginal hemorrhage, amenorrhea, dysmenorrhea, menorrhagia, breast cancer, inability to climax, and abnormal ejaculation have been reported infrequently. Kidney pain, leukorrhea, pruritus genital, renal stone, acute renal failure, anuria, glycosuria, nephrosis, nocturia, pyuria, urination urgency, vaginal pain, breast pain, and testicle pain have been reported rarely.
Musculoskeletal side effects including arthralgia have been reported frequently. Tendinitis, arthritis, joint stiffness, joint swelling, and positive Romberg test have been reported infrequently. Costochondritis, osteoporosis, bursitis, and contracture have been reported rarely. Myoclonus has also been reported. Postmarketing reports have included rhabdomyolysis and elevated creatine kinase.
General side effects have included asthenia, malaise, and facial edema which have been reported frequently. Generalized edema, weight decrease, and chill have been reported infrequently. Lassitude, "strange feelings", alcohol intolerance, and hangover effect have been reported rarely.
Endocrine side effects including hyperthyroid, hypothyroid, swollen testicle, goiter, hypoestrogenism, ovarian failure, epididymitis, and cushingoid appearance have been reported rarely. Endocrine side effects reported postmarketing have included breast enlargement.
Respiratory side effects including pneumonia have been reported frequently. Epistaxis, dyspnea, and apnea have been reported infrequently. Mucositis, aspiration pneumonia, hyperventilation, hiccup, laryngitis, nasal obstruction, snoring, bronchospasm, hypoventilation, and lung edema have been reported rarely.
Hepatic side effects including hepatomegaly have been reported infrequently. Several cases of hepatotoxicity have also been reported.
Male rats receiving doses of gabapentin (the active ingredient contained in Neurontin) of up to 2000 mg/kg for 2 years have developed acinar cell carcinoma of the pancreas.
Oncologic side effects have been reported in animal studies.
Renal side effects including two cases of marked increase in serum creatinine measurements following the introduction of gabapentin (the active ingredient contained in Neurontin) have been reported.
More Neurontin resources
- Neurontin Monograph (AHFS DI)
- Neurontin Prescribing Information (FDA)
- Neurontin Advanced Consumer (Micromedex) - Includes Dosage Information
- Neurontin MedFacts Consumer Leaflet (Wolters Kluwer)
- Neurontin Consumer Overview
- Gabapentin Prescribing Information (FDA)
- gabapentin MedFacts Consumer Leaflet (Wolters Kluwer)
- Gabapentin Professional Patient Advice (Wolters Kluwer)
- Gralise Prescribing Information (FDA)
- Gralise MedFacts Consumer Leaflet (Wolters Kluwer)
- Gralise Consumer Overview
- Horizant Consumer Overview
- Horizant Prescribing Information (FDA)
- Horizant extended-release tablets MedFacts Consumer Leaflet (Wolters Kluwer)
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