Nardil Side Effects

Please note - some side effects for Nardil may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Nardil - for the Consumer

Nardil

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Nardil:

Changes in sexual function; constipation; dizziness; drowsiness; headache; sleeping problems; tiredness; tremors; twitching; unusual muscle movements; upset stomach; weakness; weight gain.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; changes in heartbeat; chest pain; difficulty sleeping; feelings of irritability or hostility; impulsive behavior or other unusual changes in behavior; mental or mood changes; nausea; neck stiffness; panic attacks; severe anxiety or nervousness; severe headache; severe restlessness; suicidal thoughts or behaviors; urination problems; vomiting; worsening feelings of depression.

Nardil Side Effects - for the Professional

Nardil

Nardil is a potent inhibitor of monoamine oxidase. Because this enzyme is widely distributed throughout the body, diverse pharmacologic effects can be expected to occur. When they occur, such effects tend to be mild or moderate in severity, often subside as treatment continues, and can be minimized by adjusting dosage; rarely is it necessary to institute counteracting measures or to discontinue Nardil.

Common side effects include:

Nervous System—Dizziness, headache, drowsiness, sleep disturbances (including insomnia and hypersomnia), fatigue, weakness, tremors, twitching, myoclonic movements, hyperreflexia.

Gastrointestinal—Constipation, dry mouth, gastrointestinal disturbances, elevated serum transaminases (without accompanying signs and symptoms).

Metabolic—Weight gain.

Cardiovascular—Postural hypotension, edema.

Genitourinary—Sexual disturbances, eg, anorgasmia and ejaculatory disturbances and impotence.

Less common mild to moderate side effects (some of which have been reported in a single patient or by a single physician) include:

Nervous System—Jitteriness, palilalia, euphoria, nystagmus, paresthesias.

Genitourinary—Urinary retention.

Metabolic—Hypernatremia.

Dermatologic—Pruritus, skin rash, sweating.

Special Senses—Blurred vision, glaucoma.

Although reported less frequently, and sometimes only once, additional severe side effects include:

Nervous System—Ataxia, shock-like coma, toxic delirium, manic reaction, convulsions, acute anxiety reaction, precipitation of schizophrenia, transient respiratory and cardiovascular depression following ECT.

Gastrointestinal—To date, fatal progressive necrotizing hepatocellular damage has been reported in very few patients. Reversible jaundice.

Hematologic—Leukopenia.

Immunologic—Lupus-like syndrome

Metabolic—Hypermetabolic syndrome (which may include, but is not limited to, hyperpyrexia, tachycardia, tachypnea, muscular rigidity, elevated CK levels, metabolic acidosis, hypoxia, coma and may resemble an overdose).

Respiratory—Edema of the glottis.

General—Fever associated with increased muscle tone.

Withdrawal may be associated with nausea, vomiting, and malaise.

An uncommon withdrawal syndrome following abrupt withdrawal of Nardil has been infrequently reported. Signs and symptoms of this syndrome generally commence 24 to 72 hours after drug discontinuation and may range from vivid nightmares with agitation to frank psychosis and convulsions. This syndrome generally responds to reinstitution of low-dose Nardil therapy followed by cautious downward titration and discontinuation.

Side Effects by Body System

Nervous system

Nervous system side effects have included dizziness, headache, drowsiness, sleep disturbances (including insomnia and hypersomnia), fatigue, tremors, twitching, myoclonic movements, and hyperreflexia. Less common side effects have included jitteriness, euphoria, nystagmus, paresthesias, ataxia, manic reaction, and convulsions.

Gastrointestinal

Gastrointestinal side effects have included constipation, dry mouth, and gastrointestinal disturbances.

Hepatic

Hepatic side effects have included elevated serum transaminases (without accompanying signs and symptoms). Less common side effects have included reversible jaundice and fatal progressive necrotizing hepatocellular damage.

Metabolic

Metabolic side effects have included weight gain and hypernatremia. Hypermetabolic syndrome (which may include, but is not limited to, hyperpyrexia, tachycardia, tachypnea, muscular rigidity, elevated creatine kinase levels, metabolic acidosis, hypoxia, and coma) has been reported rarely and may resemble an overdose.

Cardiovascular

Cardiovascular side effects have included postural hypotension and edema.

Genitourinary

Genitourinary side effects have included sexual disturbances (e.g., anorgasmia, ejaculatory disturbances, and impotence) and urinary retention.

Dermatologic

Dermatologic side effects have included pruritus, skin rash, and sweating.

Ocular

Ocular side effects have included blurred vision and glaucoma.

Hematologic

Hematologic side effects have rarely included leukopenia.

Immunologic

Immunologic side effects have rarely included a lupus-like syndrome.

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