Nalbuphine Side Effects
Some side effects of nalbuphine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to nalbuphine: injectable solution
Get emergency medical help if you have any of these signs of an allergic reaction while taking nalbuphine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
weak or shallow breathing;
fast or slow heart rate;
cold, clammy skin;
confusion, hallucinations, unusual thoughts or behavior;
severe weakness or drowsiness; or
feeling like you might pass out.
Less serious side effects are more likely to occur, such as:
feeling nervous or restless;
stomach pain, upset stomach;
bitter taste in your mouth;
skin itching or burning, mild rash;
blurred vision, slurred speech; or
flushing (warmth, redness, or tingly feeling).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to nalbuphine: compounding powder, injectable solution
Nervous system side effects have frequently included sedation (36%), dizziness/vertigo (5%), and headache (3%). Nervousness, depression, restlessness, crying, euphoria, floating, hostility, unusual dreams, confusion, faintness, hallucinations, dysphoria, feeling of heaviness, numbness, tingling, and unreality have been reported in less than 1% of patients. A depressed level of consciousness, somnolence, tremor, anxiety, agitation. and seizures have also been reported.
Cardiovascular side effects have included hypertension, hypotension, bradycardia, and tachycardia.
Gastrointestinal side effects have frequently included nausea/vomiting (6%) and dry mouth (4%). Cramps, dyspepsia, and bitter taste have been reported in less than 1% of patients.
Respiratory side effects have included respiratory depression, dyspnea, asthma, and pulmonary edema.
Dermatologic side effects have included itching, burning, and urticaria.
Other side effects have frequently included a sweaty/clammy feeling (9%). Speech difficulty and flushing/warmth have been reported in less than 1% of patients.
Genitourinary side effects have included urinary urgency.
Ocular side effects have included blurred vision.
Hypersensitivity reactions have included anaphylactic/anaphylactoid reactions including shock, respiratory distress, respiratory arrest, bradycardia, cardiac arrest, hypotension, and laryngeal edema. Some of these allergic reactions may be life-threatening. Death has been reported following severe allergic reactions to nalbuphine. Stridor, bronchospasm, wheezing, edema, rash, pruritus, nausea, vomiting, diaphoresis, weakness, and shakiness have also been reported.
Local side effects have included pain, swelling, redness, burning, and hot sensations at the site of injection.
General side effects including abdominal pain and pyrexia have been reported.
More nalbuphine resources
- nalbuphine Concise Consumer Information (Cerner Multum)
- nalbuphine MedFacts Consumer Leaflet (Wolters Kluwer)
- nalbuphine Injection Advanced Consumer (Micromedex) - Includes Dosage Information
- Nalbuphine Prescribing Information (FDA)
- Nalbuphine Hydrochloride Monograph (AHFS DI)
- Nubain Prescribing Information (FDA)
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