Nabi-HB Novaplus Side Effects
Generic Name: hepatitis b immune globulin
Note: This page contains side effects data for the generic drug hepatitis b immune globulin. It is possible that some of the dosage forms included below may not apply to the brand name Nabi-HB Novaplus.
It is possible that some side effects of Nabi-HB Novaplus may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to hepatitis b immune globulin: solution
As well as its needed effects, hepatitis b immune globulin (the active ingredient contained in Nabi-HB Novaplus) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking hepatitis b immune globulin, check with your doctor or nurse immediately:Rare
- Blurred vision
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- unusual tiredness or weakness
- difficult or labored breathing
- difficulty with swallowing
- fast heartbeat
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- shortness of breath
- skin rash
- tightness in the chest
Some hepatitis b immune globulin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Back pain
- general feeling of discomfort
- muscle aches or pain
- pain at the injection site
- Abdominal or stomach cramping
- burning, heat, and redness at the injection site
- feeling as if you are going to vomit
- joint pain
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- cold sweats
- feeling cold
- flu-like symptoms
- upper abdominal or stomach pain
For Healthcare Professionals
Applies to hepatitis b immune globulin: injectable solution, intramuscular solution
Most side effects have been classified as mild.[Ref]
Local side effects have included erythema, pain, ecchymosis, and tenderness at the injection site.[Ref]
Hypersensitivity side effects including allergic reactions have been commonly reported. Urticaria, angioedema, and anaphylactic reactions have been reported rarely.[Ref]
Gastrointestinal side effects including nausea and vomiting have been commonly reported. Aphthous stomatitis, diarrhea, dyspepsia, and gingival hyperplasia have been reported in greater than 10% of patients.[Ref]
Other side effects have included fatigue (greater than 10%), peripheral edema (greater than 10%), pyrexia (greater than 10%), cold or flu symptoms (10%), lightheadedness (3%), fainting (3%), malaise, chills, and fever.[Ref]
Musculoskeletal side effects have been commonly reported. These have included back pain (greater than 10%), moderate low back pain, and arthralgia. Myalgia and joint stiffness have been reported.[Ref]
Hematologic side effects have included splenomegaly (greater than 10%) and decreased white blood cells.[Ref]
Hepatic side effects have included hepatobiliary disease (greater than 10%), increased AST, and alkaline phosphatase.[Ref]
Renal side effects have included nocturia (greater than 10%) and increased creatinine.[Ref]
Respiratory side effects including pleural effusion have been reported in greater than 10% of patients.
Dermatologic side effects including pruritus and rash have been reported in greater than 10% of patients.
Psychiatric side effects including agitation have been reported in greater than 10% of patients.
Immunologic side effects including liver transplant rejection, diarrhea infections, pneumonia, and sepsis have been reported in greater than 10% of patients.
Cardiovascular side effects including hypertension and hypotension have been reported in greater than 10% of patients.
Metabolic side effects have included hyperglycemia.
Nervous system side effects have included amnesia (greater than 10%), essential tremor (greater than 10%), and headache (6% to greater than 10%). At least two cases of tremor have been reported.
Ocular side effects including presbyopia have been reported in greater than 10% of patients.
1. "Product Information. Nabi-HB (hepatitis B immune globulin)." Allscripts Healthcare Solutions, Libertyville, IL.
2. "Product Information. Bayhep B (hepatitis B immune globulin)." Bayer Pharmaceutical Inc, West Haven, CT.
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