Mipomersen Side Effects

Not all side effects for mipomersen may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to mipomersen: subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by mipomersen. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking mipomersen:

More common
  • Chills
  • cough
  • dark urine
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • light-colored stools
  • loss of appetite
  • muscle aches and pains
  • nausea and vomiting
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • vomiting
  • yellow eyes and skin
Less common
  • Arm, back, or jaw pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • chest pain or discomfort
  • chest tightness or heaviness
  • fast or irregular heartbeat
  • irregular, pounding, or racing heartbeat or pulse
  • rapid weight gain
  • shortness of breath
  • sweating
  • tingling of the hands or feet
  • unusual weight gain or loss

Some of the side effects that can occur with mipomersen may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • pain in the arms or legs
Less common
  • Abdominal or stomach pain
  • joint pain
  • trouble sleeping

For Healthcare Professionals

Applies to mipomersen: subcutaneous solution

Cardiovascular

Common (1% to 10%): Hypertension (7%), angina pectoris (4%), palpitations (3%)

Dermatologic

Very common (10% or more): [All injection site reactions (84%)], erythema (59%), pain (56%), hematoma (32%), pruritus (29%), swelling (18%), discoloration (17%)

Gastrointestinal

Very common (10% or more): Nausea (14%)
Common (1% to 10%): Vomiting (4%), abdominal pain (3%)

Hepatic

Very common (10% or more): Alanine aminotransferase (ALT) increased (10%)
Common (1% to 10%): Hepatic steatosis (7%), aspartate aminotransferase (AST) increased (6%), liver function test abnormal (5%), hepatic enzyme increased (3%)

Immunologic

Rare (less than 0.1%): One case of hypersensitivity with angioedema was reported

Metabolic

Common (1% to 10%): Proteinuria (9%), peripheral edema (5%)

Musculoskeletal

Common (1% to 10%): Pain in extremity (7%), musculoskeletal pain (4%)

Nervous system

Very common (10% or more): Fatigue (15%), headache (12%)
Common (1% to 10%): Pyrexia (8%), chills (6%)

Oncologic

Common (1% to 10%): Neoplasms [benign and malignant] (4%)

Psychiatric

Common (1% to 10%): Insomnia (3%)

Renal

Rare (less than 0.1%): One case of glomerular nephritis was reported

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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