Migranal Nasal Spray Side Effects

Please note - some side effects for Migranal Nasal Spray may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects by Body System - for Healthcare Professionals

Applies to: injectable solution; nasal spray

Gastrointestinal

Gastrointestinal side effects including nausea, vomiting, and diarrhea have been reported to occur commonly.

The most frequent side effect with the use of intravenous dihydroergotamine is nausea. Following intramuscular or intranasal administration, the incidence of nausea is low.

Other

Other side effects including arterial spasm, sometimes with resulting limb necrosis, have been reported rarely. The incidence is believed to be about 1 to 3 per 100,000 patients treated for thromboprophylaxis.

Musculoskeletal

Musculoskeletal side effects including muscle cramps and weakness have been reported.

Nervous system

Nervous system side effects including drowsiness, restlessness, cerebral arteriopathy, and paresthesias have been reported.

Local

Local side effects including pain, burning, itching, edemas, and hematomas at the site of parenteral administration have been reported to occur commonly.

Cardiovascular

Cardiovascular side effects including hypertension, tachycardia, bradycardia, precordial distress, and chest pain have been reported. Myocardial ischemia and myocardial infarction have been reported rarely.

Respiratory

Respiratory side effects including pleural fibrosis have been reported following long-term high dose treatment.

Renal

Renal side effect including retroperitoneal fibrosis have been reported following long-term high dose treatment.

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