Metformin / saxagliptin Side Effects

Not all side effects for metformin / saxagliptin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to metformin / saxagliptin: oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by metformin / saxagliptin. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking metformin / saxagliptin:

More common
  • Anxiety
  • bladder pain
  • bloody or cloudy urine
  • blurred vision
  • body aches or pain
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • cough
  • depression
  • difficult, burning, or painful urination
  • difficulty with breathing
  • dizziness
  • ear congestion
  • fast heartbeat
  • fever
  • frequent urge to urinate
  • headache
  • increased hunger
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • nausea
  • nervousness
  • nightmares
  • runny nose
  • seizures
  • shakiness
  • slurred speech
  • sneezing
  • sore throat
  • unusual tiredness or weakness
Rare
  • Cough or hoarseness
Incidence not known
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • constipation
  • darkened urine
  • difficulty with swallowing
  • hives
  • indigestion
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • tightness in the chest
  • unusual bleeding or bruising
  • vomiting
  • wheezing
  • yellow eyes or skin

Some of the side effects that can occur with metformin / saxagliptin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Diarrhea
  • muscle aches
  • stuffy nose
Less common
  • Abdominal or stomach pain
  • itching
  • pain or tenderness around the eyes and cheekbones
  • redness of the skin
  • weakness
  • welts

For Healthcare Professionals

Applies to metformin / saxagliptin: oral tablet extended release

Gastrointestinal

Gastrointestinal side effects have included diarrhea, nausea, vomiting, abdominal pain, and gastroenteritis.

Metabolic

Metabolic side effects have included hypoglycemia.

Nervous system

Nervous system side effects have included headache.

Hypersensitivity

Hypersensitivity side effects have included urticaria and facial edema.

Respiratory

Respiratory side effects have included sinusitis, nasopharyngitis and upper respiratory tract infection.

Musculoskeletal

Musculoskeletal side effects have included fractures.

Hematologic

Hematologic side effects have included thrombocytopenia and lymphopenia.

Dermatologic

Dermatologic side effects have included rash.

General

General side effects have included infections, including tuberculosis.

Genitourinary

Genitourinary side effects have included urinary tract infection.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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