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Side Effects > Medroxyprogesterone

Medroxyprogesterone Side Effects

Brand Names: Provera, Depo-Provera, Depo-SubQ Provera 104

Please note - some side effects for Medroxyprogesterone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).


For the consumer

For the professional

Side Effects of Medroxyprogesterone - for the consumer


Medroxyprogesterone

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Medroxyprogesterone:

Acne; changes in menstrual flow, including breakthrough bleeding, spotting, or missed periods; dizziness; drowsiness; fever; headache; hot flashes; nausea; nervousness; pain; rash; sleeplessness; stomach pain; weakness; weight gain or loss.

Seek medical attention right away if any of these SEVERE side effects occur when using Medroxyprogesterone:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; depression; lumps in the breast or under the armpits; partial or complete loss of vision or changes in vision; shortness of breath; slurred speech; sudden loss of coordination; sudden or severe headache; swelling of fingers or ankles; tenderness, pain, or swelling of the calf; weakness, numbness, or pain in the arms or legs; yellowing of the skin or eyes.


Medroxyprogesterone Injectable Suspension

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Medroxyprogesterone Injectable Suspension:

Acne; dizziness; drowsiness; fever; headache; hot flashes; nausea; nervousness; pain, redness, and swelling at injection site; sleeplessness; weakness.

Seek medical attention right away if any of these SEVERE side effects occur when using Medroxyprogesterone Injectable Suspension:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood clots; changes in menstrual flow, including breakthrough bleeding, spotting, or missed periods; chest pain; mental or mood changes; partial or complete loss of vision or changes in vision; severe dizziness or fainting; severe stomach pain; shortness of breath; slurred speech; sudden loss of coordination; sudden or severe headache or vomiting; swelling of fingers or ankles; unusual weight gain or loss; weakness, numbness, or pain in the arms or legs; yellowing of the skin or eyes.


Medroxyprogesterone Injectable Suspension (subcutaneous)

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Medroxyprogesterone Injectable Suspension (subcutaneous):

Acne; changes in menstrual flow, including breakthrough bleeding, spotting, or missed periods; dizziness; drowsiness; fever; headache; hot flashes; nausea; nervousness; pain; rash; sleeplessness; stomach pain; weakness; weight gain or loss.

Seek medical attention right away if any of these SEVERE side effects occur when using Medroxyprogesterone Injectable Suspension (subcutaneous):

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood clots; chest pain; depression; partial or complete loss of vision or changes in vision; shortness of breath; slurred speech; sudden loss of coordination; sudden or severe headache; swelling of fingers or ankles; weakness, numbness, or pain in the arms or legs; yellowing of the skin or eyes.

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For the professional


Medroxyprogesterone

Breast

Breast tenderness or galactorrhea has been reported.

Skin

Sensitivity reactions consisting of urticaria, pruritus, edema and generalized rash have occurred. Acne, alopecia and hirsutism have been reported.

Thromboembolic Phenomena

Thromboembolic phenomena including thrombophlebitis and pulmonary embolism have been reported.

Other

The following adverse reactions have been observed in women taking progestins, including Medroxyprogesterone acetate tablets:

  
breakthrough bleeding
  
spotting
  
change in menstrual flow
  
amenorrhea
  
edema
  
change in weight (increase or decrease)
  
changes in cervical erosion and cervical secretions
  
cholestatic jaundice
  
anaphylactoid reactions and anaphylaxis
  
rash (allergic) with and without pruritus
  
mental depression
  
pyrexia
  
insomnia
  
nausea
  
somnolence

Although available evidence is suggestive of an association, such a relationship has been neither confirmed nor refuted for the following serious adverse reactions: neuro-ocular lesions, eg, retinal thrombosis and optic neuritis.

The following adverse reactions have been observed in patients receiving estrogen-progestin combination drugs:

  
rise in blood pressure in susceptible individuals
  
premenstrual-like syndrome
  
changes in libido
  
changes in appetite
  
cystitis-like syndrome
  headache
  nervousness
  
fatigue
  
backache
  
hirsutism
  
loss of scalp hair
  
erythema multiforme
  
erythema nodosum 
  
hemorrhagic
  eruption
  itching
  dizziness

Laboratory Tests

The following laboratory results may be altered by the use of estrogen-progestin combination drugs:

Increased sulfobromophthalein retention and other hepatic function tests.
Coagulation tests: increase in prothrombin factors VII, VIII, IX and X.
Metyrapone test.
Pregnanediol determination.

Thyroid function: increase in PBI, and butanol extractable protein bound iodine and decrease in T3 uptake values.

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More resources:

Drugs.com Depo-Provera

PDR Provera

PDR Depo-Provera

MedFacts Medroxyprogesterone

MedFacts Depo-Provera Injectable Suspension

Micromedex Medroxyprogesterone - Includes detailed dosage instructions.

FDA Provera

FDA Medroxyprogesterone

FDA Depo-Provera

FDA Depo-SubQ Provera 104

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