Medroxyprogesterone Acetate Side Effects
Generic Name: Medroxyprogesterone
Please note - some side effects for Medroxyprogesterone Acetate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).
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For the professional
Medroxyprogesterone Acetate
Breast:
Breast tenderness or galactorrhea has been reported.
Skin:
Sensitivity reactions consisting of urticaria, pruritus, edema and generalized rash have occurred. Acne, alopecia and hirsutism have been reported.
Thromboembolic Phenomena:
Thromboembolic phenomena including thrombophlebitis and pulmonary embolism have been reported.
Other:
The following adverse reactions have been observed in women taking progestins, including Medroxyprogesterone Acetate tablets:
breakthrough bleeding
cholestatic jaundice
spotting
anaphylactoid reactions and anaphylaxis rash (allergic) with and without pruritus
change in menstrual flow
amenorrhea
edema
change in weight (increase or decrease)
mental depression
pyrexia
changes in cervical erosion and cervical secretions
insomnia
nausea
somnolence
Although available evidence is suggestive of an association, such a relationship has been neither confirmed nor refuted for the following serious adverse reactions:
neuro-ocular lesions, e.g., retinal thrombosis and optic neuritis.
The following adverse reactions have been observed in patients receiving estrogen-progestin combination drugs:
rise in blood pressure in susceptible individuals
fatigue
backache
hirsutism
premenstrual-like syndrome
loss of scalp hair
erythema multiforme
changes in libido
erythema nodosum
hemorrhagic eruption
changes in appetite
cystitis-like syndrome
headache
itching
nervousness
dizziness
Laboratory Tests:
The following laboratory results may be altered by the use of estrogen-progestin combination drugs:
Increased sulfobromophthalein retention and other hepatic function tests.
Coagulation tests: increase in prothrombin factors VII, VIII, IX and X.
Metyrapone test.
Pregnanediol determination.
Thyroid function: increase in PBI, and butanol extractable protein bound iodine and decrease in T3 uptake values.
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