Maprotiline Side Effects

Brand Names: Ludiomil

Please note - some side effects for Maprotiline may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Maprotiline - for the consumer

Maprotiline

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Maprotiline:

Anxiety or nervousness; blurred vision; constipation; dizziness; drowsiness; dry mouth; headache; nausea; tiredness; upset stomach; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in sexual function; confusion; delusions; disorientation; fast or irregular heartbeat; fainting; fever; hallucinations; involuntary movements of tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements), sometimes accompanied by involuntary movements of the arms and legs; lightheadedness; ringing in the ears; seizures; severe or persistent nervousness or anxiety; sore throat; tremors; trouble sleeping; trouble urinating; unusual bleeding or bruising; yellowing of the skin or eyes.

For the professional

Maprotiline

The following adverse reactions have been noted with Maprotiline and are generally similar to those observed with tricyclic antidepressants.

Cardiovascular: Rare occurrences of hypotension, hypertension, tachycardia, palpitation, arrhythmia, heart block, and syncope have been reported with Maprotiline.

Psychiatric: Nervousness (6%), anxiety (3%), insomnia (2%), and agitation (2%); rarely, confusional states (especially in the elderly), hallucinations, disorientation, delusions, restlessness, nightmares, hypomania, mania, exacerbation of psychosis, decrease in memory, and feelings of unreality.

Neurological: Drowsiness (16%), dizziness (8%), tremor (3%), and, rarely, numbness, tingling, motor hyperactivity, akathisia, seizures, EEG alterations, tinnitus, extrapyramidal symptoms, ataxia, and dysarthria.

Anticholinergic: Dry mouth (22%), constipation (6%), and blurred vision (4%); rarely, accommodation disturbances, mydriasis, urinary retention, and delayed micturition.

Allergic: Rare instances of skin rash, petechiae, itching, photosensitization, edema, and drug fever.

Gastrointestinal: Nausea (2%) and, rarely, vomiting, epigastric distress, diarrhea, bitter taste, abdominal cramps and dysphagia.

Endocrine: Rare instances of increased or decreased libido, impotence, and elevation or depression of blood sugar levels.

Other: Weakness and fatigue (4%) and headache (4%); rarely, altered liver function, jaundice, weight loss or gain, excessive perspiration, flushing, urinary frequency, increased salivation, nasal congestion and alopecia.

Note: Although there have been only isolated reports of the following adverse reactions with Maprotiline, its pharmacologic similarity to tricyclic antidepressants requires that each reaction be considered when administering Maprotiline.

    — Bone marrow depression, including agranulocytosis, eosinophilia, purpura, and thrombocytopenia, myocardial infarction, stroke, peripheral neuropathy, sublingual adenitis, black tongue, stomatitis, paralytic ileus, gynecomastia in the male, breast enlargement and galactorrhea in the female, and testicular swelling.

Postintroduction Reports

Voluntary reports of adverse events temporally associated with Maprotiline that have been received since market introduction and that may have no casual relationship with the drug include the following: interstitial pneumonitis which were in some cases associated with eosinophilia and increased liver enzymes, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

More resources:

maprotiline

Maprotiline

Maprotiline - Includes detailed dosage instructions.

Maprotiline

Ludiomil

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