Magnevist Side Effects

Generic Name: gadopentetate dimeglumine

Note: This page contains information about the side effects of gadopentetate dimeglumine. Some of the dosage forms included on this document may not apply to the brand name Magnevist.

Not all side effects for Magnevist may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to gadopentetate dimeglumine: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by gadopentetate dimeglumine (the active ingredient contained in Magnevist). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking gadopentetate dimeglumine, check with your doctor or nurse immediately:

Rare
  • Arm, back, or jaw pain
  • bluish color
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • changes in skin color
  • chest pain or discomfort
  • chest tightness or heaviness
  • chills
  • confusion
  • cough
  • difficult or labored breathing
  • difficulty with swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • headache, severe and throbbing
  • hives
  • irritation of the throat
  • itching
  • loss of bladder control
  • loss of consciousness
  • nausea
  • nervousness
  • noisy breathing
  • pain or swelling of the treated skin
  • paleness of the skin
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red or irritated eyes
  • redness, tenderness, itching, burning, or peeling of the skin
  • runny nose
  • seizures
  • shortness of breath
  • skin rash
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • stuffy nose
  • sweating
  • swelling of the foot or leg
  • swelling or puffiness of the face
  • tenderness
  • total body jerking
  • unusual tiredness or weakness
  • wheezing
Incidence not known
  • Agitation
  • blistering, peeling, or loosening of the skin
  • bluish color of the fingernails, lips, skin, palms, or nail beds
  • burning or itching of the skin
  • change in consciousness
  • coma
  • coughing that sometimes produces a pink frothy sputum
  • decreased urine output
  • depression
  • diarrhea
  • difficult, fast, or noisy breathing, sometimes with wheezing
  • difficulty with speaking
  • frequent strong or increased urge to urinate
  • hoarseness
  • hostility
  • increased sweating
  • irritability
  • joint or muscle pain
  • joint stiffness
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lethargy
  • limited range of motion in the arms and legs
  • muscle twitching or weakness
  • no blood pressure or pulse
  • no breathing
  • pain that is deep in the hip bone or ribs
  • pain, redness, or swelling in the arm or leg
  • rapid weight gain
  • red or dark patches on the skin
  • shakiness in the legs, arms, hands, or feet
  • skin swelling, hardening, or tightening
  • slow or irregular breathing
  • sores, ulcers, or white spots in the mouth or on the lips
  • spots on your skin resembling a blister or pimple
  • stopping of heart
  • stupor
  • swelling of the face, ankles, or hands
  • tenderness
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • troubled breathing
  • unconsciousness

Some of the side effects that can occur with gadopentetate dimeglumine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
Rare
  • Abdominal or stomach discomfort or pain
  • bad, unusual, or unpleasant (after) taste
  • burning, dry, or itching eyes
  • change in taste
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decrease or change in vision
  • difficulty having a bowel movement (stool)
  • discharge or excessive tearing
  • double vision
  • dry mouth
  • ear pain
  • eye pain
  • feeling cold or warm
  • hearing loss
  • hives or welts
  • hyperventilation
  • increased salivation
  • lack or loss of strength
  • loss of appetite
  • nervousness
  • pain in the tooth
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • restlessness
  • seeing double
  • skin rash
  • sleepiness or unusual drowsiness
  • tearing of the eyes
  • thirst
  • trouble sleeping
  • uncontrolled eye movements
  • vomiting
  • weight loss
Incidence not known
  • Blurred or loss of vision
  • change in sense of smell
  • difficulty with moving
  • disturbed color perception
  • double vision
  • halos around lights
  • muscle pain or stiffness
  • night blindness
  • overbright appearance of lights
  • poor hearing
  • tunnel vision

For Healthcare Professionals

Applies to gadopentetate dimeglumine: injectable solution

Cardiovascular

Cardiovascular side effects have included hypotension, hypertension, arrhythmia, tachycardia, syncope, vasodilation, pallor, nonspecific ECG changes, angina pectoris, death related to myocardial infarction, phlebitis, thrombophlebitis, deep venous thrombophlebitis, and compartment syndrome requiring surgery.[Ref]

Gastrointestinal

Gastrointestinal side effects have included gastrointestinal distress, stomach pain, increased salivation, abdominal pain, vomiting, constipation, thirst, anorexia, dry mouth, and diarrhea.[Ref]

Nervous system

Nervous system side effects have included agitation, anxiety, migraine, nystagmus, drowsiness, stupor, paresthesia, and convulsions.[Ref]

Ocular

Ocular side effects have included diplopia, conjunctivitis, visual field defect, lacrimation disorder, eye irritation, and eye pain.[Ref]

Respiratory

Respiratory side effects have included throat irritation, rhinorrhea, sneezing, dyspnea, wheezing, laryngismus, cough, and respiratory complaints.[Ref]

Dermatologic

Dermatologic side effects have included rash, sweating, pruritus, urticaria, facial edema, erythema multiforme, epidural necrolysis, and pustules.[Ref]

Local

Local side effects have included pain, localized warmth, and burning sensation at the injection site.[Ref]

Hypersensitivity

Hypersensitivity side effects have included substernal chest pain, back pain, fever, weakness, generalized coldness, generalized warmth, localized edema, tiredness, chest tightness, trembling, shivering, tension in the extremities, regional lymphangitis, pelvis pain, and anaphylactoid reactions.[Ref]

Other

Other side effects have included tinnitus and taste abnormalities.[Ref]

References

1. "Product Information. Magnevist (gadopentetate dimeglumine)." Berlex Laboratories, Wayne, NJ.

2. Tardy B, Guy C, Barral G, Page Y, Ollagnier M, Bertrand JC "Anaphylactic shock induced by intravenous gadopentetate dimeglumine." Lancet 339 (1992): 494

3. Garcia N, Ramon E, Gonzalez del Valle L, Ruano M, Jimenez E "Importance of a previous allergy to an iodinated contrast agent in the administration of gadopentetate dimeglumine." Ann Pharmacother 31 (1997): 374

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