Lyza Side Effects

Generic name: norethindrone

Medically reviewed by Drugs.com. Last updated on Mar 22, 2024.

Note: This document contains side effect information about norethindrone. Some dosage forms listed on this page may not apply to the brand name Lyza.

Applies to norethindrone: oral tablet.

Serious side effects of Lyza

Along with its needed effects, norethindrone (the active ingredient contained in Lyza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking norethindrone:

More common

Frequent and irregular bleeding
menstrual changes

Incidence not known

Blindness
blue-yellow color blindness
blurred vision
breast pain
changes in menstrual period
changes in vision
chest tightness
chills
clay-colored stools
confusion
cough
dark urine
decreased vision
diarrhea
difficulty with swallowing
discouragement
dizziness
double vision
eye pain
fast heartbeat
feeling sad or empty
fever
general tiredness and weakness
headache
heavy non-menstrual vaginal bleeding
hives, itching, or rash
irritability
lack of appetite
light-colored stools
light vaginal bleeding between regular menstrual periods
loss of interest or pleasure
migraine headache
nausea and vomiting
numbness of the hands
pain, redness, or swelling in the arm or leg
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
stomach pain
swelling
trouble concentrating
trouble sleeping
unpleasant breath odor
unusual tiredness or weakness
upper right abdominal or stomach pain
vomiting of blood
yellow eyes and skin

Other side effects of Lyza

Some side effects of norethindrone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Breast tenderness
increased hair growth, especially on the face
pimples
weight gain

Incidence not known

Brown, blotchy spots on exposed skin
enlarged breasts
loss or thinning of the hair
mood swings
nervousness
weight changes

For Healthcare Professionals

Applies to norethindrone: compounding powder, oral tablet.

General

The most commonly reported side effects included cycle irregularity, spotting/breakthrough bleeding, and temporary amenorrhea.^[Ref]

Genitourinary

Common (1% to 10%): Uterine/vaginal bleeding and spotting/breakthrough bleeding, short-lasting amenorrhea

Uncommon (0.1% to 1%): Breast discomfort

Frequency not reported: Irregular/increased/decreased bleeding/delayed menstruation, change in menstrual flow, menorrhagia, vaginal hemorrhage, cervical secretion alteration, cervical erosions, prolonged anovulation, suppressed lactation, galactorrhea, mastodynia, breast tenderness/enlargement, genital discharge, withdrawal bleeding (on treatment discontinuation), premenstrual-type depression, changes in cervical squamocolumnar junction and secretions^[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Frequency not reported: Drowsiness, somnolence, concentration loss, migraine, tremor, cerebral thrombosis and embolism^[Ref]

Local

Common (1% to 10%): Injection site reaction, local skin reaction^[Ref]

Gastrointestinal

Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Bloating

Frequency not reported: Vomiting, abdominal pain, gastrointestinal disturbance^[Ref]

Dermatologic

Common (1% to 10%): Skin disorder

Frequency not reported: Angioedema, acne, hirsutism, alopecia, rash, pruritus, pruritic rash, melasma, chloasma, urticaria, exacerbation of existing skin conditions, sweating, allergic rash with and without pruritus^[Ref]

Metabolic

Common (1% to 10%): Increased weight

Frequency not reported: Increased fasting insulin levels, Cushing's syndrome, decreased glucose tolerance, exacerbation of diabetes mellitus, glycosuria, weight gain/change, change in appetite, fluid retention, increased serum calcium and potassium levels, altered serum lipid and lipoprotein levels (e.g., decreased HDL, increased LDL/HDL ratio)^[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity reaction

Frequency not reported: Anaphylaxis/anaphylactoid reactions^[Ref]

Psychiatric

Uncommon (0.1% to 1%): Depressed mood/depression/clinical depression/metal depression

Frequency not reported: Insomnia, nervousness, libido change, mood swings^[Ref]

Respiratory

Frequency not reported: Urge to cough, paroxysmal cough, respiratory distress, dyspnea, pulmonary embolism, voice deepening^[Ref]

Ocular

Frequency not reported: Retinal thrombosis, diabetic cataract, vision disorders, visual disturbance, contact lens intolerance, optic neuritis (may lead to partial or complete vision loss)^[Ref]

Cardiovascular

Frequency not reported: Circulatory irregularity, thromboembolic disorders, thrombophlebitis, increased blood pressure/hypertension, edema^[Ref]

Hepatic

Frequency not reported: Cholestatic liver changes/cholestatic jaundice, hepatitis, disturbed liver function, transient liver test abnormalities (e.g., AST, ALT, bilirubin)^[Ref]