Lurasidone Side Effects

Not all side effects for lurasidone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to lurasidone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by lurasidone. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking lurasidone:

More common
  • Absence of or decrease in body movement
  • difficulty with swallowing
  • drooling
  • inability to sit still
  • incremental or ratchet-like movement of the muscle
  • loss of balance control
  • mask-like face
  • muscle discomfort
  • muscle trembling, jerking, or stiffness
  • need to keep moving
  • restlessness
  • rigid or stiff muscles
  • shakiness in the legs, arms, hands, or feet
  • shuffling walk
  • slow movements
  • slow reflexes
  • slurred speech
  • stiffness of the arms and legs
  • tic-like (jerky) movements of the head, face, mouth, and neck
  • trembling or shaking of the hands or feet
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
Less common
  • Arm, back, or jaw pain
  • blurred vision
  • burning while urinating
  • changes in patterns and rhythms of speech
  • chest pain or discomfort
  • chills
  • cold sweats
  • confusion
  • convulsions
  • difficult or painful urination
  • difficulty opening the mouth
  • difficulty with breathing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • fixed position of the eye
  • headache
  • high fever
  • inability to move the eyes
  • inability to speak
  • increased blinking or spasms of the eyelid
  • increased sweating
  • lockjaw
  • loss of bladder control
  • muscle spasm, especially of the neck and back
  • nervousness
  • pale skin
  • pounding in the ears
  • seizures
  • severe muscle stiffness
  • severe or sudden headache
  • shortness of breath
  • slow or fast heartbeat
  • slurred speech
  • sticking out of the tongue
  • sweating
  • temporary blindness
  • tiredness
  • trouble with breathing, speaking, or swallowing
  • troubled breathing with exertion
  • uncontrolled twisting movements of the neck, trunk, arms, or legs
  • unusual bleeding or bruising
  • unusual facial expressions
  • unusual tiredness or weakness
  • unusually pale skin
  • weakness in the arm or leg on one side of the body, sudden and severe
Rare
  • Black, tarry stools
  • bloody urine
  • breast pain or swelling
  • cough
  • dark-colored urine
  • decreased frequency or amount of urine
  • fever
  • increased thirst
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • lower back or side pain
  • muscle cramps or spasms
  • muscle pain or stiffness
  • nausea
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the face, fingers, or lower legs
  • swollen glands
  • troubled breathing
  • vomiting
  • weight gain

Some of the side effects that can occur with lurasidone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Acid or sour stomach
  • anxiety
  • belching
  • drowsiness
  • dry mouth
  • heartburn
  • hyperventilation
  • indigestion
  • irritability
  • relaxed and calm
  • sleepiness or unusual drowsiness
  • sleeplessness
  • stomach discomfort, upset, or pain
  • trouble sleeping
  • unable to sleep
  • unusually deep sleep
  • unusually long duration of sleep
Less common
  • Abnormal dreams
  • anxiety
  • back pain
  • blurred vision
  • burning feeling in the chest or stomach
  • decreased appetite
  • diarrhea
  • feeling of constant movement of self or surroundings
  • indigestion
  • itching
  • sensation of spinning
  • skin rash
  • sweating
  • tenderness in the stomach area
  • watering of mouth and drooling
Rare
  • Decreased interest in sexual intercourse
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • unexpected or excess milk flow from the breasts

For Healthcare Professionals

Applies to lurasidone: oral tablet

Nervous system

Nervous system side effects have included hypersomnia, hypersomnolence, sedation, somnolence, bradykinesia, cogwheel rigidity, drooling, extrapyramidal disorder, hypokinesia, muscle rigidity, parkinsonism, psychomotor retardation, tremor, dystonia, oculogyric crisis, oromandibular dystonia, tongue spasm, torticollis, and trismus. Other side effects have included tardive dyskinesia, cerebrovascular accident, dysarthria, syncope, neuroleptic malignant syndrome, and seizure.

Psychiatric

Psychiatric side effects have included insomnia, agitation, anxiety, abnormal dreams, panic attack, sleep disorder, suicidal behavior, and restlessness.

Cardiovascular

Cardiovascular side effects have included tachycardia, hypertension, orthostatic hypotension, 1st degree AV block, angina pectoris, syncope, and bradycardia.

Gastrointestinal

Gastrointestinal side effects have included decreased appetite, nausea, vomiting, dyspepsia, abdominal pain, gastritis, diarrhea, dysphagia, and salivary hypersecretion.

General

General side effects have included fatigue and sudden death.

Hematologic

Hematologic side effects have included anemia, leucopenia, and neutropenia.

Musculoskeletal

Musculoskeletal side effects have included back pain and rhabdomyolysis.

Dermatologic

Dermatologic side effects have included rash, pruritus, and angioedema.

Genitourinary

Genitourinary side effects have included amenorrhea, dysmenorrhea, breast enlargement, breast pain, galactorrhea, and erectile dysfunction.

Renal

Renal side effects have included dysuria and renal failure.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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