Loxitane C Side Effects

Generic Name: loxapine

Note: This page contains side effects data for the generic drug loxapine. It is possible that some of the dosage forms included below may not apply to the brand name Loxitane C.

It is possible that some side effects of Loxitane C may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to loxapine: oral capsule, oral solution, oral tablet

Other dosage forms:

As well as its needed effects, loxapine (the active ingredient contained in Loxitane C) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking loxapine, check with your doctor immediately:

More common
  • Difficulty with speaking or swallowing
  • lip smacking or puckering
  • loss of balance control
  • mask-like face
  • puffing of the cheeks
  • rapid or fine, worm-like movements of the tongue
  • restlessness or desire to keep moving
  • shuffling walk
  • slowed movements
  • stiffness of the arms and legs
  • trembling and shaking of the fingers and hands
  • uncontrolled chewing movements
  • uncontrolled movements of the arms or legs
Less common
  • Constipation (severe)
  • difficult urination
  • inability to move the eyes
  • muscle spasms, especially of the neck and back
  • skin rash
  • twisting movements of the body
  • Convulsions (seizures)
  • difficult or fast breathing
  • fast heartbeat or irregular pulse
  • fever (high)
  • high or low blood pressure
  • increased blinking or spasms of the eyelid
  • increased sweating
  • loss of bladder control
  • muscle stiffness (severe)
  • sore throat and fever
  • uncontrolled twisting movements of neck, trunk, arms, or legs
  • unusual bleeding or bruising
  • unusual facial expressions or body positions
  • unusual tiredness or weakness
  • unusually pale skin
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking loxapine:

Symptoms of overdose
  • Dizziness (severe)
  • drowsiness (severe)
  • muscle trembling, jerking, stiffness, or uncontrolled movements (severe)
  • troubled breathing (severe)
  • unusual tiredness or weakness (severe)

Some loxapine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Blurred vision
  • confusion
  • dizziness, lightheadedness, or fainting
  • drowsiness
  • dryness of the mouth
Less common
  • Constipation (mild)
  • decreased sexual ability
  • enlargement of breasts (males and females)
  • headache
  • increased sensitivity of the skin to sun
  • missing menstrual periods
  • nausea or vomiting
  • trouble with sleeping
  • unusual secretion of milk
  • weight gain

For Healthcare Professionals

Applies to loxapine: inhalation powder, intramuscular solution, oral capsule, oral concentrate

Nervous system

Nervous system side effects including Neuroleptic malignant syndrome (NMS), agitation, drowsiness, dizziness, faintness, staggering gait, tremor, shuffling gait, muscle twitching, weakness, insomnia, tension, rigidity, excessive salivation, akathisia, muscle spasms in neck and face, tongue protrusion, seizures, akinesia, paresthesia, slurred speech, numbness, and confusion have been frequently reported.


Cardiovascular side effects including tachycardia, hypotension, hypertension, orthostatic hypotension, light-headedness, increased pulse rate, and syncope have been reported.


Gastrointestinal side effects including nausea, vomiting, and constipation have been reported.


Hematologic side effects including agranulocytosis, thrombocytopenia, and leukopenia have rarely been reported.


Genitourinary side effects including urinary retention, increase in prolactin levels, galactorrhea, amenorrhea, gynecomastia, and menstrual irregularity have been reported.


Ocular side effects including blurred vision, oculogyric movement, ptosis, pigmentary retinopathy, and lenticular pigmentation have been reported.


Hepatic side effects including hepatocellular injury, increased SGOT/SGPT levels, jaundice, and hepatitis have rarely been reported.


Dermatologic side effects including dermatitis, edema, pruritus, rash, alopecia, and seborrhea have been reported.


Respiratory side effects including dyspnea have been infrequently reported.


General side effects including dry mouth, weight gain, weight loss, headache, hyperpyrexia, and polydipsia have been reported.

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