Loperamide / simethicone Side Effects
Medically reviewed by Drugs.com. Last updated on Jan 4, 2024.
Applies to loperamide / simethicone: oral tablet.
Warning
- Do not take more than the package label says or your doctor told you to take. Taking more than you were told can cause very bad heart problems, including an abnormal heartbeat. Sometimes, these heart problems can lead to death. Taking this drug with certain other drugs may also raise the chance of heart problems. Talk with your doctor.
- Do not give to a child younger than 2 years of age.
Serious side effects
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Very bad dizziness or passing out.
- Chest pain or pressure or a fast heartbeat.
- A heartbeat that does not feel normal.
- Very upset stomach or throwing up.
- Belly pain.
- Constipation.
- Swelling of belly.
- Fever.
- Black, tarry, or bloody stools.
- Not able to pass urine or change in how much urine is passed.
Other side effects
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Dizziness.
- Feeling sleepy.
- Feeling tired or weak.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
For Healthcare Professionals
Applies to loperamide/simethicone: oral tablet, oral tablet chewable.
Gastrointestinal
Common (1% to 10%): Constipation, flatulence, vomiting
Uncommon (0.1% to 1%): Abdominal discomfort, abdominal distention, abdominal pain, dry mouth, dyspepsia, upper abdominal pain
Rare (0.01% to 0.1%): Ileus (including paralytic ileus), megacolon (including toxic megacolon)[Ref]
Nervous system
Common (1% to 10%): Dizziness, dysgeusia, headache
Uncommon (0.1% to 1%): Somnolence
Rare (0.01% to 0.1%): Coordination abnormality, depressed level of consciousness, hypertonia, loss of consciousness, stupor
Frequency not reported: Drowsiness[Ref]
Dermatologic
Uncommon (0.1% to 1%): Rash
Rare (0.01% to 0.1%): Bullous eruptions, erythema multiforme, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria[Ref]
Other
Uncommon (0.1% to 1%): Asthenia
Rare (0.01% to 0.1%): Fatigue
Frequency not reported: Tiredness[Ref]
Hypersensitivity
Rare (0.01% to 0.1%): Anaphylactic reaction, anaphylactic shock, anaphylactoid reaction, angioedema, hypersensitivity reaction[Ref]
Genitourinary
Rare (0.01% to 0.1%): Urinary retention[Ref]
Ocular
Rare (0.01% to 0.1%): Miosis[Ref]
Frequently asked questions
More about loperamide / simethicone
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- During pregnancy
- Drug class: antidiarrheals
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References
1. Product Information. Imodium Advanced (loperamide-simethicone). Johnson and Johnson/Merck. 2006.
2. Cerner Multum, Inc. UK Summary of Product Characteristics.
3. Cerner Multum, Inc. Australian Product Information.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
