Liptruzet Side Effects

Generic Name: atorvastatin / ezetimibe

Note: This page contains information about the side effects of atorvastatin / ezetimibe. Some of the dosage forms included on this document may not apply to the brand name Liptruzet.

Not all side effects for Liptruzet may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to atorvastatin / ezetimibe: oral tablet

In addition to its needed effects, some unwanted effects may be caused by atorvastatin / ezetimibe. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking atorvastatin / ezetimibe:

Less common
  • Abdominal or stomach pain
  • confusion
  • difficult breathing
  • difficulty with moving
  • irregular heartbeat
  • muscle, joint, or bone pain
  • muscle stiffness
  • muscle weakness
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • weakness or heaviness of the legs
Incidence not known
  • Black, tarry stools
  • blistering, peeling, or loosening of the skin
  • blood in the urine or stools
  • chills
  • dark-colored urine
  • diarrhea
  • fever
  • gaseous abdominal or stomach pain
  • general tiredness and weakness
  • hives, welts, or skin rash
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • severe nausea or vomiting
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the eyes, face, or inside of the nose
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes and skin

Some of the side effects that can occur with atorvastatin / ezetimibe may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Cough
  • dizziness
  • feeling of warmth
  • pain or tenderness around the eyes and cheekbones
  • redness of the face, neck, arms, and occasionally, upper chest
  • stuffy or runny nose
  • sudden sweating
  • tightness in the chest
Incidence not known
  • Being forgetful
  • bloating burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chills
  • constipation
  • discouragement
  • fast heartbeat
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • loss of memory
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • tiredness
  • trouble concentrating
  • trouble sleeping

For Healthcare Professionals

Applies to atorvastatin / ezetimibe: oral tablet

Dermatologic

Postmarketing reports: Angioedema, bullous rashes (including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis), rash, urticaria

Endocrine

Common (1% to 10%): Hot flushes (2%)

Gastrointestinal

Common (1% to 10%): Diarrhea (4.1 to 6.8%), abdominal pain (3%), nausea (3 to 4%), dyspepsia (4.7%)

Genitourinary

Common (1% to 10%): Urinary tract infection (5.7%)

Hematologic

Postmarketing reports: Thrombocytopenia, elevated creatine phosphokinase

Hepatic

Common (1% to 10%): ALT increased (5%), AST increased (4%)
Postmarketing reports: Hepatitis, cholelithiasis, cholecystitis, fatal and nonfatal hepatic failure

Hypersensitivity

Postmarketing reports: Anaphylaxis, hypersensitivity reactions

Immunologic

Common (1% to 10%): Influenza (2%)

Metabolic

Common (1% to 10%): Hyperkalemia (2%)

Musculoskeletal

Common (1% to 10%): Musculoskeletal pain (3.8 to 4%), arthralgia (3 to 6.9%), pain in extremity (2.7 to 6%), myalgia (3.5%), muscle spasms (3%), muscle weakness (2%)
Postmarketing reports: Myopathy/rhabdomyolysis, necrotizing myopathy (rarely), injury, poisoning and procedural complication, tendon rupture

Nervous system

Common (1% to 10%): Dizziness (2 to 6%), insomnia (3%), fatigue (2.4%)
Postmarketing reports: Headache, paresthesia, peripheral neuropathy, amnesia, memory impairment, confusion, depression

Respiratory

Common (1% to 10%): Coughing (2 to 3%), bronchitis (2%), sinusitis (2 to 2.8%), upper respiratory tract infection (4.3%), nasopharyngitis (up to 8.3%), pharyngolaryngeal pain (up to 2.3%)

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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