Lidocaine / prilocaine topical Side Effects
Not all side effects for lidocaine / prilocaine topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to lidocaine / prilocaine topical: topical application cream, topical application film, topical application kit
Other dosage forms:
In addition to its needed effects, some unwanted effects may be caused by lidocaine / prilocaine topical. In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking lidocaine / prilocaine topical:Rare
- difficulty with swallowing
- large, hive-like swellings on the eyelids, face, lips, or tongue
- severe dizziness or feeling faint
- shortness of breath
- skin rash, itching, or hives
- stuffy nose
- tightness in the chest
- troubled breathing
- Blisters on skin at application site
- blue or blue-purple color of lips, fingernails, mouth, or skin
- blurred or double vision
- dark urine
- dizziness or drowsiness
- feeling hot, cold, or numb
- irregular or fast heartbeat
- muscle twitching or trembling
- nausea or vomiting
- ringing or buzzing in the ears
- shortness of breath or troubled breathing
- unusual excitement, nervousness, or restlessness
- unusual tiredness or weakness
Some of the side effects that can occur with lidocaine / prilocaine topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common
- Burning, swelling, itching, or skin rash at application site
- white or red skin at the application site
For Healthcare Professionals
Applies to lidocaine / prilocaine topical: topical cream, topical film, topical kit
Local side effects have included erythema, edema, and abnormal sensation. Local effects observed in the trials of the cream on intact skin have included paleness (37%), erythema (30%), alterations in temperature sensations (7%), edema (6%), itching (2%), and rash (<1%). The most commonly reported local side effects in clinical studies on genital mucous membranes were redness (21%), burning sensation (17%), and edema (10%).
Cardiovascular side effects have included bradycardia, hypotension, and cardiovascular collapse leading to arrest.
Nervous system side effects have included CNS excitation and/or depression. Excitatory CNS reactions may be brief or not occur at all.
Hypersensitivity side effects have included angioedema, bronchospasm, and shock.
Dermatologic side effects have included urticaria. The detection of sensitivity by skin testing is of doubtful value.
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