Lidocaine/prilocaine Side Effects

Please note - some side effects for Lidocaine/prilocaine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Lidocaine/prilocaine - for the Consumer

Lidocaine/prilocaine Cream

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Lidocaine/prilocaine Cream:

Abnormal skin sensations; burning; change in hot or cold sensation; pale skin; redness or swelling at the application site.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Applies to: topical cream; topical film; topical kit

Local

Local side effects have included erythema, edema, and abnormal sensation. Local effects observed in the trials of the cream on intact skin have included paleness (37%), erythema (30%), alterations in temperature sensations (7%), edema (6%), itching (2%), and rash (<1%). The most commonly reported local side effects in clinical studies on genital mucous membranes were redness (21%), burning sensation (17%), and edema (10%).

Cardiovascular

Cardiovascular side effects have included bradycardia, hypotension, and cardiovascular collapse leading to arrest.

Nervous system

Nervous system side effects have included CNS excitation and/or depression. Excitatory CNS reactions may be brief or not occur at all.

Hypersensitivity

Hypersensitivity side effects have included angioedema, bronchospasm, and shock.

Dermatologic

Dermatologic side effects have included urticaria. The detection of sensitivity by skin testing is of doubtful value.

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