Lidex-E Side Effects

Generic Name: fluocinonide topical

Note: This page contains side effects data for the generic drug fluocinonide topical. It is possible that some of the dosage forms included below may not apply to the brand name Lidex-E.

It is possible that some side effects of Lidex-E may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to fluocinonide topical: topical application cream, topical application emollient cream, topical application gel/jelly, topical application ointment, topical application solution

As well as its needed effects, fluocinonide topical (the active ingredient contained in Lidex-E) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking fluocinonide topical, check with your doctor immediately:

Incidence not known
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • irritation
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • redness and scaling around the mouth
  • thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (e.g. between the fingers)
  • thinning, weakness, or wasting away of the skin

Some fluocinonide topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Fever
  • headache
  • muscle aches
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness
Incidence not known
  • Acne or pimples
  • burning and itching of the skin with pinhead-sized red blisters
  • burning, itching, and pain in hairy areas, or pus at the root of the hair
  • increased hair growth on the forehead, back, arms, and legs
  • lightening of normal skin color
  • lightening of treated areas of dark skin
  • reddish purple lines on the arms, face, legs, trunk, or groin
  • softening of the skin

For Healthcare Professionals

Applies to fluocinonide topical: compounding powder, topical cream, topical gel, topical ointment, topical solution

Local

Skin atrophy may become evident within one to two months of use and is due to the inhibitory effect of corticosteroids on collagen formation. Skin on the face, axilla, and groin appears to be most susceptible to the adverse long-term effects of topical fluocinonide. Use of high potency topical corticosteroids on these areas should be minimized or avoided.

Topical corticosteroid use may inhibit local immune response rendering the skin more susceptible to infections. Folliculitis is occasionally reported.

Perioral dermatitis or rosacea-like dermatitis has occurred in patients treated with potent topical corticosteroids who are of seborrheic skin type. This condition may flare temporarily upon discontinuation of topical steroids, prompting patients to continue their use. If topical corticosteroids are discontinued, this flare and the initial dermatitis generally resolves over a few weeks.

Worsening of psoriasis has occurred in a few patients.

Local side effects have commonly included burning, itching, dryness, or irritation, especially when applied to denuded skin. Long-term use of topical corticosteroids has resulted in skin atrophy and thinning, and the development of striae, telangiectasia, subcutaneous hemorrhage, easy bruising, and bleeding. Allergic contact dermatitis has been occasionally reported.

Endocrine

Endocrine side effects have included rare reports of hypothalamic-pituitary-adrenal (HPA) axis suppression. These reports were generally cases when higher potency topical corticosteroids were used over extensive areas and when occlusive dressings were used. HPA axis suppression has not been reported with fluocinonide.

In one study, six patients received fluocinonide cream applied to 75% of their body (approximately 14 grams) every day for six days. No indication of HPA axis suppression was seen when compared with placebo.

Nervous system

Nervous system side effects have included headache.

Respiratory

Respiratory system side effects have included nasopharyngitis and nasal congestion.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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