Levoleucovorin calcium Side Effects

It is possible that some side effects of levoleucovorin calcium may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to levoleucovorin calcium: intravenous powder for solution

As well as its needed effects, levoleucovorin calcium may cause unwanted side effects that require medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking levoleucovorin calcium:

More common
  • Cloudy urine
  • decrease in urine output or decrease in urine-concentrating ability
  • difficult or labored breathing
  • fever
  • general feeling of discomfort or illness
  • lack or loss of strength
  • shortness of breath
  • stomach cramps, tenderness, or pain
  • tightness in the chest
  • unusual tiredness or weakness
  • watery or bloody diarrhea
  • wheezing
Incidence not known
  • Feeling unusually cold
  • shivering

Some levoleucovorin calcium side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Acid or sour stomach
  • bad, unusual, or unpleasant (after) taste
  • belching
  • blistering, crusting, irritation, itching, reddening, or swelling of the skin
  • burning, tingling, numbness, or pain in the hands, arms, feet, or legs
  • change in taste
  • cracked, dry, or scaly skin
  • decreased appetite
  • diarrhea
  • hair loss or thinning of the hair
  • heartburn
  • indigestion
  • loss of appetite
  • mood or mental changes
  • nausea
  • sensation of pins and needles
  • stabbing pain
  • stomach discomfort or upset
  • swelling or inflammation of the mouth
  • vomiting
  • weight loss
Incidence not known
  • Rash

For Healthcare Professionals

Applies to levoleucovorin calcium: intravenous powder for injection


Gastrointestinal side effects including stomatitis (37.5%), vomiting (37.5%), nausea (18.8%), diarrhea (6.3%), dyspepsia (6.3%), and typhlitis (6.3%) have been reported.


Respiratory side effects including dyspnea (6.3%) have been reported.


Dermatologic side effects including dermatitis (6.3%), pruritus, and rash have been reported.


Other side effects including confusion (6.3%), taste perversion (6.3), temperature change, and rigors have been reported.

Nervous system

Nervous system side effects including neuropathy (6.3%) have been reported.


Renal side effects including abnormal renal function (6.3%) have been reported.


Other side effects including confusion (6.3%), taste perversion (6.3), temperature change, and rigors have been reported.

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