Leukeran Side Effects
Generic Name: chlorambucil
Note: This document contains side effect information about chlorambucil. Some of the dosage forms listed on this page may not apply to the brand name Leukeran.
Some side effects of Leukeran may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to chlorambucil: oral tablet
Along with its needed effects, chlorambucil (the active ingredient contained in Leukeran) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking chlorambucil:More common
- Black, tarry stools
- bleeding gums
- blood in the urine or stools
- chest pain
- cough or hoarseness, accompanied by fever or chills
- fever or chills
- lower back or side pain, accompanied by fever or chills
- painful or difficult urination, accompanied by fever or chills
- pinpoint red spots on the skin
- shortness of breath
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
- joint pain
- large, swollen hives
- skin rash
- swelling of the feet or lower legs
- Blistering, peeling, or loosening of the skin
- muscle pain
- muscle twitching
- red skin lesions, often with a purple center
- red, irritated eyes
- shakiness and unsteady walk
- shakiness in the legs, arms, hands, or feet
- sore throat
- sudden jerky movements of the body
- unsteadiness, trembling, or other problems with muscle control or coordination
- Abdominal or stomach pain or tenderness
- bone pain
- clay colored stools
- dark urine
- decreased appetite
- difficult breathing
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- trouble getting pregnant
- troubled or quick, shallow breathing
- yellow eyes or skin
Some side effects of chlorambucil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- Changes in menstrual period
- nausea and vomiting
- dry mouth
- irregular heartbeats
- no muscle tone or movement
- seeing, hearing, or feeling things that are not there
- trouble sleeping
- Hives or welts
For Healthcare Professionals
Applies to chlorambucil: compounding powder, oral tablet
Bone marrow suppression has been reported to usually be reversible if chlorambucil (the active ingredient contained in Leukeran) is withdrawn early enough. However, irreversible bone marrow failure has been reported.
Hematologic side effects including bone marrow suppression have been the most commonly reported with the use of chlorambucil. Anemia, leukopenia, neutropenia, thrombocytopenia, and pancytopenia have also been reported.
Most nervous system effects have been reported to resolve upon discontinuation of the drug.
The manufacturer has noted that children with nephrotic syndrome and patients receiving high pulse doses of chlorambucil (the active ingredient contained in Leukeran) may have an increased risk of seizures.
Nervous system side effects including coma, tremors, muscular twitching, confusion, agitation, ataxia, flaccid paresis, hallucinations, and focal and/or generalized seizures have been reported rarely. Peripheral neuropathy has also been reported.
Dermatologic side effects have included skin hypersensitivity with rare reports of skin rash progressing to erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson syndrome.
Gastrointestinal side effects including nausea, vomiting, diarrhea, and oral ulceration have been reported infrequently. Jaundice has also been reported.
Respiratory side effects including pulmonary fibrosis and interstitial pneumonia have been reported.
Hepatic side effects including hepatotoxicity have been reported. A case of chlorambucil-induced acute hepatic failure has been reported in a patient with membranous nephropathy.
Genitourinary side effects including sterile cystitis and infertility have been reported.
Oncologic side effects including leukemia and secondary malignancies have been reported.
General side effects including drug fever have been reported.
Ocular side effects including one case of visual failure and optic atrophy have been reported.
Psychiatric side effects including lethargy and stupor have been reported.
More about Leukeran (chlorambucil)
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