Kristalose Side Effects
Generic name: lactulose
Note: This document contains side effect information about lactulose. Some of the dosage forms listed on this page may not apply to the brand name Kristalose.
Some side effects of Kristalose may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to lactulose: oral and rectal liquid, oral powder for reconstitution, oral syrup
Get emergency medical help if you have any of these signs of an allergic reaction while taking lactulose (the active ingredient contained in Kristalose) hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using lactulose and call your doctor at once if you have severe or ongoing diarrhea.
Less serious side effects of lactulose may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to lactulose: compounding solution, oral powder for reconstitution, oral syrup, oral and rectal liquid
Diarrhea is an indication of overdose. Severe diarrhea may lead to hypovolemia, hypokalemia, and hypernatremia, especially in elderly or acutely ill patients. If diarrhea develops, the dosage should be reduced.
Pneumatosis cystoides intestinalis may occur with lactulose (the active ingredient contained in Kristalose) therapy as a result of increased intracolonic pressure caused by ammonia sequestration in the bowel, and particularly when there is a concomitant breach of intestinal mucosal integrity.
Gastrointestinal side effects have included abdominal cramps, gaseous distention, flatulence, belching, bowel distention, cramping, nausea and vomiting, and with excessive doses, diarrhea. Colonic dilatation has been reported in elderly patients. Rare cases of pneumatosis cystoides intestinalis have been reported.
Metabolic side effects have included hypernatremia, hypokalemia and hyperchloremic metabolic acidosis. An isolated case of severe and intractable lactic acidosis has been reported.
Fluid and electrolyte disturbances, including severe hypokalemia, hypernatremia and hyperchloremic metabolic acidosis, typically occur as a result of severe diarrhea and subsequent fluid loss. A case of fatal lactulose-induced lactic acidosis in the absence of diarrhea has also been reported. Elderly and/or acutely ill patients may be at increased risk for adverse metabolic effects with lactulose.
More Kristalose resources
- Kristalose crystals MedFacts Consumer Leaflet (Wolters Kluwer)
- Kristalose Concise Consumer Information (Cerner Multum)
- Kristalose Prescribing Information (FDA)
- Lactulose Prescribing Information (FDA)
- Lactulose Professional Patient Advice (Wolters Kluwer)
- Lactulose Monograph (AHFS DI)
- Constulose solution MedFacts Consumer Leaflet (Wolters Kluwer)
- Constulose Prescribing Information (FDA)
- Enulose solution MedFacts Consumer Leaflet (Wolters Kluwer)
- Enulose Prescribing Information (FDA)
- Generlac Prescribing Information (FDA)
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