Kinevac Side Effects

Generic name: sincalide

Note: This document contains side effect information about sincalide. Some of the dosage forms listed on this page may not apply to the brand name Kinevac.

Some side effects of Kinevac may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to sincalide: intravenous powder for injection

Get emergency medical help if you have any of these signs of an allergic reaction while taking sincalide (the active ingredient contained in Kinevac) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects are more likely, such as:

• stomach pain or discomfort;

• nausea, vomiting, diarrhea;

• headache;

• feeling light-headed or short of breath;

• sweating, flushing (warmth, redness, or tingly feeling);

• sneezing; or

• mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to sincalide: intravenous powder for injection

Gastrointestinal

Gastrointestinal side effects have included abdominal discomfort or pain and nausea. Rapid IV injection of 0.04 mcg sincalide (the active ingredient contained in Kinevac) per kg would be expected to cause transient abdominal cramping. These side effects are usually manifestations of the physiologic action of the drug, including delayed gastric emptying and increased intestinal motility. These side effects occurred in approximately 20% of patients but they are not to be construed as necessarily indicating an abnormality of the biliary tract unless there is other clinical or radiologic evidence of disease.

General

Reactions to sincalide (the active ingredient contained in Kinevac) are usually mild and of short duration. Adverse reactions including vomiting, flushing, sweating, rash, hypotension, hypertension, shortness of breath, urge to defecate, headache, diarrhea, sneezing, and numbness were less than 1%. Dizziness was reported in approximately 2% of patients. These manifestations are usually attenuated by a slower injection rate.

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