Kinevac Side Effects

Generic Name: sincalide

Note: This page contains information about the side effects of sincalide. Some of the dosage forms included on this document may not apply to the brand name Kinevac.

Not all side effects for Kinevac may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to sincalide: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by sincalide (the active ingredient contained in Kinevac). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking sincalide, check with your doctor or nurse as soon as possible:

Less common or rare
  • Dizziness, fainting, or lightheadedness
  • increase in blood pressure
  • shortness of breath
  • skin rash

Some of the side effects that can occur with sincalide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Abdominal or stomach pain, cramps, or discomfort
  • nausea
Less common or rare
  • Diarrhea
  • dizziness
  • flushing or redness of skin
  • headache
  • increased sweating
  • numbness
  • sneezing
  • urge to have bowel movement
  • vomiting

For Healthcare Professionals

Applies to sincalide: injectable powder for injection, intravenous powder for injection

Gastrointestinal

Gastrointestinal side effects have included abdominal discomfort or pain and nausea. Rapid IV injection of 0.04 mcg sincalide (the active ingredient contained in Kinevac) per kg would be expected to cause transient abdominal cramping. These side effects are usually manifestations of the physiologic action of the drug, including delayed gastric emptying and increased intestinal motility. These side effects occurred in approximately 20% of patients but they are not to be construed as necessarily indicating an abnormality of the biliary tract unless there is other clinical or radiologic evidence of disease.

General

Reactions to sincalide (the active ingredient contained in Kinevac) are usually mild and of short duration. Adverse reactions including vomiting, flushing, sweating, rash, hypotension, hypertension, shortness of breath, urge to defecate, headache, diarrhea, sneezing, and numbness were less than 1%. Dizziness was reported in approximately 2% of patients. These manifestations are usually attenuated by a slower injection rate.

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