Kantrex Side Effects

Generic name: kanamycin

Note: This document contains side effect information about kanamycin. Some of the dosage forms listed on this page may not apply to the brand name Kantrex.

Some side effects of Kantrex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to kanamycin: injectable solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking kanamycin (the active ingredient contained in Kantrex) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using kanamycin and call your doctor at once if you have any of these serious side effects:

• changes in your hearing;

• spinning sensation, problems with balance;

• ringing or roaring sound in your ears;

• numbness or tingling of your skin;

• muscle twitching, seizure (convulsions); or

• urinating less than usual or not at all.

Less serious side effects of kanamycin may include:

• pain or irritation where the injection was given;

• mild skin rash;

• headache;

• fever; or

• nausea, vomiting.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

For Healthcare Professionals

Applies to kanamycin: compounding powder, injectable solution, oral capsule

General

The major toxic effects associated with kanamycin (the active ingredient contained in Kantrex) therapy are ototoxicity and nephrotoxicity. It is considered one of the more toxic aminoglycosides.

Nervous system

Nervous system side effects have included neuromuscular blockade, ototoxicity resulting in loss of vestibular function secondary to hair cell damage, and irreversible or partially reversible bilateral hearing loss. Nystagmus, vertigo, nausea, vomiting, and acute Meniere's syndrome are signs of vestibular dysfunction. Cochlear damage may be asymptomatic and may initially manifest as minor changes in audiometric test results at higher frequencies. Aminoglycosides have been associated with acute muscular paralysis, apnea, peripheral neuropathy and encephalopathy (numbness, paresthesia, muscle twitching, seizures), and myasthenia gravis-like syndrome. Neurotoxicity may occur after intrapleural, intraperitoneal, or parenteral administration. Patients with renal impairment may be at a higher risk.

Renal

Renal side effects have included nephrotoxicity, albuminuria, presence of red and white cells and granular casts, azotemia, oliguria, and increased serum creatinine and BUN.

Dermatologic

Dermatologic reactions have included skin rash.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, and diarrhea.

Local

Local reactions have included pain at the injection site after intramuscular injection.

Metabolic

Metabolic side effects associated with prolonged kanamycin (the active ingredient contained in Kantrex) treatment have included malabsorption syndrome manifested as increased fecal fat, decreased serum carotene, and decreased xylose absorption.

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