Kanamycin Side Effects

Brand Names: Kantrex

Please note - some side effects for Kanamycin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Kanamycin - for the Consumer

Kanamycin

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Kanamycin:

Diarrhea; nausea; pain, redness, or swelling at the injection site; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decreased urination; dizziness; hearing loss; increased or difficult urination; lightheadedness; loss of hearing; muscle weakness; numbness or tingling; ringing or roaring in the ears; vaginal irritation or discharge.

Side Effects by Body System

General

The major toxic effects associated with kanamycin therapy are ototoxicity and nephrotoxicity. It is considered one of the more toxic aminoglycosides.

Nervous system

Nervous system side effects have included neuromuscular blockade, ototoxicity resulting in loss of vestibular function secondary to hair cell damage, and irreversible or partially reversible bilateral hearing loss. Nystagmus, vertigo, nausea, vomiting, and acute Meniere's syndrome are signs of vestibular dysfunction. Cochlear damage may be asymptomatic and may initially manifest as minor changes in audiometric test results at higher frequencies. Aminoglycosides have been associated with acute muscular paralysis, apnea, peripheral neuropathy and encephalopathy (numbness, paresthesia, muscle twitching, seizures), and myasthenia gravis-like syndrome. Neurotoxicity may occur after intrapleural, intraperitoneal, or parenteral administration. Patients with renal impairment may be at a higher risk.

Renal

Renal side effects have included nephrotoxicity, albuminuria, presence of red and white cells and granular casts, azotemia, oliguria, and increased serum creatinine and BUN.

Dermatologic

Dermatologic reactions have included skin rash.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, and diarrhea.

Local

Local reactions have included pain at the injection site after intramuscular injection.

Metabolic

Metabolic side effects associated with prolonged kanamycin treatment have included malabsorption syndrome manifested as increased fecal fat, decreased serum carotene, and decreased xylose absorption.

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