Kanamycin Side Effects
It is possible that some side effects of kanamycin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to kanamycin: oral capsule
Other dosage forms:
As well as its needed effects, kanamycin may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking kanamycin, check with your doctor immediately:Rare - with long-term use and high doses
- Any loss of hearing
- greatly decreased frequency of urination or amount of urine
- increased thirst
- ringing or buzzing or a feeling of fullness in the ears
Some kanamycin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- nausea or vomiting
- Increased amount of gas
- light-colored, frothy, fatty-appearing stools
For Healthcare Professionals
Applies to kanamycin: compounding powder, injectable solution, oral capsule
The major toxic effects associated with kanamycin therapy are ototoxicity and nephrotoxicity. It is considered one of the more toxic aminoglycosides.
Nervous system side effects have included neuromuscular blockade, ototoxicity resulting in loss of vestibular function secondary to hair cell damage, and irreversible or partially reversible bilateral hearing loss. Nystagmus, vertigo, nausea, vomiting, and acute Meniere's syndrome are signs of vestibular dysfunction. Cochlear damage may be asymptomatic and may initially manifest as minor changes in audiometric test results at higher frequencies. Aminoglycosides have been associated with acute muscular paralysis, apnea, peripheral neuropathy and encephalopathy (numbness, paresthesia, muscle twitching, seizures), and myasthenia gravis-like syndrome. Neurotoxicity may occur after intrapleural, intraperitoneal, or parenteral administration. Patients with renal impairment may be at a higher risk.
Renal side effects have included nephrotoxicity, albuminuria, presence of red and white cells and granular casts, azotemia, oliguria, and increased serum creatinine and BUN.
Dermatologic reactions have included skin rash.
Gastrointestinal side effects have included nausea, vomiting, and diarrhea.
Local reactions have included pain at the injection site after intramuscular injection.
Metabolic side effects associated with prolonged kanamycin treatment have included malabsorption syndrome manifested as increased fecal fat, decreased serum carotene, and decreased xylose absorption.
More about kanamycin
- Other brands: Kantrex
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