Juxtapid Side Effects

Generic Name: lomitapide

Note: This page contains information about the side effects of lomitapide. Some of the dosage forms included on this document may not apply to the brand name Juxtapid.

Not all side effects for Juxtapid may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to lomitapide: oral capsule

In addition to its needed effects, some unwanted effects may be caused by lomitapide (the active ingredient contained in Juxtapid). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking lomitapide:

More common
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • dark urine
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • light-colored stools
  • loss of appetite
  • nausea and vomiting
  • shortness of breath
  • sweating
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Some of the side effects that can occur with lomitapide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Acid or sour stomach
  • back pain
  • belching
  • chills
  • constipation
  • cough
  • decreased weight
  • diarrhea
  • dizziness
  • excess air or gas in the stomach or intestines
  • frequent urge to defecate
  • full or bloated feeling
  • general feeling of discomfort or illness
  • headache
  • heartburn
  • indigestion
  • joint pain
  • muscle aches and pains
  • passing gas
  • pressure in the stomach
  • shivering
  • sore throat
  • stomach discomfort, upset, or pain
  • straining while passing stool
  • stuffy or runny nose
  • sweating
  • swelling of the abdominal or stomach area
  • trouble sleeping
  • weakness

For Healthcare Professionals

Applies to lomitapide: oral capsule

Cardiovascular

Very common (10% or more): Chest pain (24%), angina pectoris (10%), palpitations (10%)

Gastrointestinal

Very common (10% or more): Diarrhea (79%), nausea (65%), dyspepsia (38%), vomiting (34%), abdominal pain (34%), abdominal discomfort (21%), abdominal distention (21%), constipation (21%), flatulence (21%), gastroesophageal reflux disease (10%), defecation urgency ((10%), rectal tenesmus (10%), gastroenteritis (14%)

Hepatic

Very common (10% or more): Increased ALT (17%), at least one elevation in ALT and/or AST greater than or equal to 3 times ULN (29%), hepatic steatosis: of 23 patients in a study for 78 weeks, 18 (78%) exhibited an increase in hepatic fat greater than 5% and 3 (13%) exhibited an increase greater than 20%

Immunologic

Very common (10% or more): Influenza (21%)

Metabolic

Very common (10% or more): Weight loss (24%)

Nervous system

Very common (10% or more): Fatigue (17%), fever (10%), headache (10%), dizziness (10%)

Respiratory

Very common (10% or more): Nasopharyngitis (17%), pharyngolaryngeal pain (14%), nasal congestion (10%)

Dermatologic

Common (1% to 10%): Ecchymosis, papule, rash erythematous, xanthoma

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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