Juvisync Side Effects
Generic name: simvastatin / sitagliptin
Note: This document contains side effect information about simvastatin / sitagliptin. Some of the dosage forms listed on this page may not apply to the brand name Juvisync.
Some side effects of Juvisync may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to simvastatin / sitagliptin: oral tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking simvastatin / sitagliptin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
In rare cases, simvastatin and sitagliptin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Stop using simvastatin and sitagliptin and call your doctor at once if you have:
confusion, memory problems;
swelling, weight gain, urinating less than usual or not at all;
severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate;
increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss;
itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
cold symptoms such as stuffy nose, sneezing, sore throat;
constipation, mild stomach pain, mild nausea;
dizziness, tingly feeling;
depression, memory problems, sleep problems (insomnia);
headache, joint pain; or
trouble having an erection.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to simvastatin / sitagliptin: oral tablet
Endocrine side effects have included hypoglycemia, pancreatitis, acute pancreatitis, including fatal and nonfatal hemorrhagic and necrotizing pancreatitis, hepatitis/jaundice, fatal and nonfatal hepatic failure, and hepatic enzyme elevations.
Gastrointestinal side effects have included constipation, gastritis, abdominal pain, nausea, dyspepsia, flatulence, and diarrhea.
Musculoskeletal side effect shave included muscle cramps, myalgia, arthralgia, and myopathy/rhabdomyolysis.
Postmarketing reports have included pain in extremities and back pain.
Respiratory side effects have included bronchitis, sinusitis, upper respiratory tract infection, nasopharyngitis, and interstitial lung disease.
Nervous system side effects have included headache, insomnia, asthenia, paresthesia, dizziness, peripheral neuropathy, vertigo, and cognitive impairment (e.g., memory loss, forgetfulness, amnesia, memory impairment, confusion).
Hypersensitivity side effects have included reactions such as anaphylaxis, angioedema, rash, urticaria, cutaneous vasculitis, and exfoliative skin conditions including Stevens-Johnson syndrome.
Cardiovascular side effects have included atrial fibrillation.
Genitourinary side effects have included urinary tract infection and erectile dysfunction.
Dermatologic side effects have included eczema, rash, pruritus, alopecia, and a variety of skin changes (e.g., nodules, discoloration, dryness of skin/mucous membranes, changes to hair/nails).
General side effects have included edema and swelling.
Renal side effects have included worsening renal function, including acute renal failure (sometimes requiring dialysis).
Postmarketing reports have included anemia.
Postmarketing reports have included depression.
More Juvisync resources
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