Jentadueto Side Effects

Generic name: linagliptin / metformin

Note: This document contains side effect information about linagliptin / metformin. Some of the dosage forms listed on this page may not apply to the brand name Jentadueto.

Some side effects of Jentadueto may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to linagliptin / metformin: oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking linagliptin / metformin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as:

• muscle pain or weakness;

• numb or cold feeling in your arms and legs;

• trouble breathing;

• feeling dizzy, light-headed, tired, or very weak;

• stomach pain, nausea with vomiting; or

• slow or uneven heart rate.

Stop using this medicine and call your doctor at once if you have a serious side effect such as:

• swelling, rapid weight gain; or

• severe pain in your upper stomach spreading to your back, nausea and vomiting, and fast heart rate.

Less serious side effects of linagliptin / metformin may include:

• cough, sore throat

• sinus pain, stuffy nose;

• upset stomach, diarrhea; or

• weight gain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to linagliptin / metformin: oral tablet

Respiratory

Respiratory side effects have included cough and nasopharyngitis.

Hypersensitivity

Hypersensitivity side effects have included urticaria, angioedema, bronchial hyperactivity, and localized skin exfoliation.

Musculoskeletal

Musculoskeletal side effects have included myalgia.

Gastrointestinal

Gastrointestinal side effects have included diarrhea, flatulence, indigestion, abdominal discomfort, decreased appetite, nausea, vomiting, and pancreatitis.

Nervous system

Nervous system side effects have included headache and asthenia.

Dermatologic

Dermatologic side effects have included pruritus.

Metabolic

Metabolic side effects of long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption which may very rarely result in clinically significant vitamin B12 deficiency (e.g., megaloblastic anemia).

Endocrine

Endocrine side effects have included hypoglycemia.

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