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Januvia Side Effects

Generic Name: sitagliptin

Note: This page contains information about the side effects of sitagliptin. Some of the dosage forms included on this document may not apply to the brand name Januvia.

Not all side effects for Januvia may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to sitagliptin: oral tablet

In addition to its needed effects, some unwanted effects may be caused by sitagliptin (the active ingredient contained in Januvia). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking sitagliptin:

Less common
  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • confusion
  • cool, pale skin
  • depression
  • dizziness
  • fast heartbeat
  • headache
  • increased hunger
  • loss of consciousness
  • nausea
  • nervousness
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • unusual tiredness or weakness

Some of the side effects that can occur with sitagliptin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Body aches or pain
  • cough
  • difficulty with breathing
  • ear congestion
  • fever
  • loss of voice
  • muscle aches
  • sneezing
  • sore throat
  • stuffy or runny nose
Less common
  • Abdominal or stomach pain
  • diarrhea

For Healthcare Professionals

Applies to sitagliptin: oral tablet


Metabolic side effects have included hypoglycemia.[Ref]


Gastrointestinal side effects have included abdominal pain, nausea, and diarrhea. Postmarketing experience has included constipation, vomiting, acute pancreatitis, including fatal and nonfatal hemorrhagic and necrotizing pancreatitis.[Ref]


Respiratory side effects have included nasopharyngitis and upper respiratory tract infection.[Ref]

Nervous system

Nervous system side effects have included headache.[Ref]


Hypersensitivity side effects have included anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome. Postmarketing hypersensitivity reactions have included rash, urticaria, and cutaneous vasculitis.


Hepatic side effects have included postmarketing reports of hepatic enzyme elevations.


Renal side effects have included postmarketing reports of worsening renal function, including acute renal failure, sometimes requiring dialysis.


Arthralgia, myalgia, pain in extremities, and back pain have been reported postmarketing.


1. "Product Information. Januvia (sitagliptin)." Merck & Company Inc, West Point, PA.

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