Side Effects > Isocarboxazid

Isocarboxazid Side Effects

Brand Names: Marplan

Please note - some side effects for Isocarboxazid may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Isocarboxazid - for the Consumer

Isocarboxazid

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Isocarboxazid:

Abnormal skin sensations; anxiety; blurred vision; chills; constipation; diarrhea; dizziness; drowsiness; dry mouth; fainting; forgetfulness; frequent urination; headache; heavy feeling; hyperactivity; inability to urinate; lack of energy; lightheadedness when rising from a seated or lying position; muscle jerks; nausea; sedation; sleep disturbance; sleeplessness; tremors; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur when using Isocarboxazid:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; chest pain; cold, clammy skin; difficulty sleeping; fast or irregular heartbeat; feelings of irritability or hostility; impotence; impulsive behavior or other unusual change in behavior; nausea; neck stiffness; panic attacks; pounding in the chest; sensitivity to light; severe headache; severe high blood pressure; severe nervousness or anxiety; severe restlessness; suicidal thoughts or behaviors; sweating; tightness in the throat or chest; vomiting; widened pupils; worsening feelings of depression; yellowing of the eyes or skin.

Top

Side Effects by Body System

Cardiovascular

Cardiovascular side effects have included orthostatic hypotension (4%), syncope (3%), and palpitations (2%). Hypertensive crises have also been reported with MAO inhibitor therapy. Decreases in systolic and diastolic blood pressures have also been reported.

Hypertensive crisis can occur during isocarboxazid therapy and is characterized by some or all of the following symptoms: occipital headache that may radiate frontally, palpitation, neck stiffness or soreness, nausea or vomiting, sweating that is sometimes accompanied by fever or cold, clammy skin, pupil dilatation, photophobia, tachycardia or bradycardia, and constricting chest pain. Intracranial bleeding, which can be fatal, has also been reported with the paradoxical increase in blood pressure. Hypertensive crises may be precipitated by concomitant administration of sympathomimetic drugs or related compounds or other MAO inhibitors. Ingestion of foods with a high concentration of tyramine or dopamine and excessive amounts of caffeine and chocolate may also cause a hypertensive crisis. Blood pressure should be monitored frequently in all patients and therapy discontinued immediately upon the occurrence of palpitation or frequent headaches, as these signs may be prodromal of a hypertensive crisis.

Nervous system

Nervous system side effects have included dizziness (up to 32%), headache (up to 15%), insomnia (up to 10%), sedation (up to 6%), sleep disturbances (up to 5%), drowsiness (up to 4%), tremor (up to 4%), paresthesia (up to 2%), anxiety (up to 2%), chills (up to 2%), forgetfulness (up to 3%), nightmares (up to 2%), mood elevation (up to 2%), hyperactivity (up to 2%), numbness (up to 1%), hyperreflexia (up to 1%), nervousness (up to 1%), restlessness (up to 1%), racing thoughts (up to 1%), photophobia (up to 1%), and panic (up to 1%). Other less common nervous system side effects have included akathisia, ataxia, hallucinations, neuritis, and coma.

Gastrointestinal

Gastrointestinal side effects have included dry mouth (up to 13%), constipation (up to 8%), nausea (up to 6%), diarrhea (up to 2%), increased appetite (up to 2%), decreased appetite (up to 1%), craving sweets (up to 1%), and bitter taste (up to 1%).

Ocular

Ocular side effects have included blurred vision (6%).

Musculoskeletal

Musculoskeletal side effects have included heavy feeling (up to 2%), muscle contractions (up to 2%), and myoclonic jerks (up to 2%).

Genitourinary

Genitourinary side effects have included urinary hesitancy (up to 4%), impotence (up to 2%), urinary frequency (up to 2%), urinary retention (up to 2%), and orgasmic dysfunction (up to 2%). Other less common genitourinary side effects have included dysuria, ejaculatory dysfunction, decreased libido, and continence.

General

General side effects have included peripheral edema (up to 5%), weakness (up to 3%), chills (up to 2%), lethargy (up to 2%), sweating (up to 2%), pains (up to 1%), and facial swelling (up to 1%).

Hepatic

Hepatic side effects have included elevated serum glutamate pyruvate transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT).

Endocrine

Endocrine side effects of MAO inhibitors have included hypoglycemic episodes and impaired water excretion compatible with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).

Dermatologic

Dermatologic side effects have included rash (up to 1%).

Top

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.