Ipratropium nasal Side Effects

Not all side effects for ipratropium nasal may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ipratropium nasal: nasal spray

In addition to its needed effects, some unwanted effects may be caused by ipratropium nasal. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking ipratropium nasal:

For the 0.03% nasal sprayMore common
  • Body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • ear congestion
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • runny nose
  • sneezing
  • sore throat
  • unusual tiredness or weakness
Less common
  • Blurred vision
  • burning, dry, or itching eyes
  • discharge or excessive tearing
  • itching, redness, tearing, or other sign of eye irritation not present before use of this medicine or becoming worse during use
  • nasal dryness
  • nosebleeds
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
Rare
  • Pain or cramping in the abdomen or stomach
  • painful or difficult urination
Incidence not known
  • Difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives or welts
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • skin rash
  • tightness in the chest
For the 0.06% nasal spray used for 4 daysLess common
  • Nasal dryness
  • nosebleeds
Rare
  • Blurred vision
  • dizziness
  • eye redness or pain
  • fast, slow, or irregular heartbeat
  • pain or cramping in the abdomen or stomach
  • painful or difficult urination
  • ringing or buzzing in the ears
  • sore throat

Some of the side effects that can occur with ipratropium nasal may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

For the 0.03% nasal sprayLess common or rare
  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • dry mouth or throat
  • increased nasal congestion or runny nose
  • nasal itching, burning, or irritation
  • nausea
For the 0.06% nasal sprayLess common or rare
  • Dry mouth or throat
  • increased nasal congestion

For Healthcare Professionals

Applies to ipratropium nasal: nasal spray

General

Ipratropium has been generally well-tolerated, and void of systemic effects when administered intranasally.[Ref]

Local

Local side effects have included blood-tinged mucus (17%), nasal dryness (10%), epistaxis (7%), and nasal irritation (2%).[Ref]

Nervous system

Nervous system side effects have included headache is reported in approximately 9% of the patients treated with the nasal spray. Dizziness has occurred infrequently.[Ref]

Hypersensitivity

Hypersensitivity side effects have included reports of allergic-type reactions including skin rash, angioedema of the throat, tongue, lips,and face, generalized urticaria, laryngospasm, and anaphylactic reactions.[Ref]

Ocular

Ocular side effects have included blurred vision and conjunctivitis after the medication came in contact with the eyes.[Ref]

Genitourinary

Genitourinary side effects have not been usually observed with the low doses given by nasal spray. Urinary retention has been reported occasionally in patients receiving larger doses by nebulizer. Caution may be warranted when using ipratropium in men with prostatic hypertrophy.[Ref]

Respiratory

Respiratory side effects have included pharyngitis and upper respiratory tract infection has been reported in 8% and 9% of patients, respectively.[Ref]

Cardiovascular

Cardiovascular side effects have included rare reports of tachycardia and palpitations.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea and diarrhea.[Ref]

Dermatologic

Dermatologic side effects have included rare reports of skin rash.[Ref]

References

1. Gross NJ "Ipratropium bromide." N Engl J Med 319 (1988): 486-94

2. Massey KL, Gotz VP "Ipratropium bromide." Drug Intell Clin Pharm 19 (1985): 5-12

3. "Product Information. Atrovent nasal spray (ipratropium nasal)." Boehringer-Ingelheim, Ridgefield, CT.

4. Dockhorn R, Grossman J, Posner M, Zinny M, Tinkleman D "A double-blind, placebo-controlled study of the safety and efficacy of ipratropium bromide nasal spray versus placebo in patients with the common cold." J Allergy Clin Immunol 90 (1992): 1076-82

5. Hayden FG, Diamond L, Wood PB, Korts DC, Wecker MT "Effectiveness and safety of intranasal ipratropium bromide in common colds: a randomized, double-blind, placebo-controlled trial." Ann Intern Med 125 (1996): 89-97

6. Milford CA, Mugliston TA, Lund VJ, Mackay IS "Long-term safety and efficacy study of intranasal ipratropium bromide." J Laryngol Otol 104 (1990): 123-5

7. Lozewicz S "Bladder outflow obstruction induced by ipratropium bromide." Postgrad Med J 65 (1989): 260-1

8. O'Driscoll BR "Supraventricular tachycardia caused by nebulised ipratropium bromide." Thorax 44 (1989): 312

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