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Insulin Pork Mix Side Effects

Generic Name: insulin isophane / insulin regular

Note: This page contains information about the side effects of insulin isophane / insulin regular. Some of the dosage forms included on this document may not apply to the brand name Insulin Pork Mix.

Not all side effects for Insulin Pork Mix may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to insulin isophane / insulin regular: subcutaneous suspension

Get emergency medical help if you have any of these signs of insulin allergy: itching skin rash over the entire body, wheezing, trouble breathing, fast heart rate, sweating, or feeling like you might pass out.

Call your doctor at once if you have shortness of breath, swelling in your hands or feet, or rapid weight gain (especially if you are taking an oral diabetes medication).

Hypoglycemia, or low blood sugar, is the most common side effect of insulin. Symptoms of low blood sugar may include headache, hunger, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Watch for signs of low blood sugar. Carry a piece of non-dietetic hard candy or glucose tablets with you in case you have low blood sugar.

Tell your doctor if you have itching, swelling, redness, or thickening of the skin where you inject insulin isophane and insulin regular.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to insulin isophane / insulin regular: subcutaneous suspension


Adverse reactions observed with insulin therapy include hypoglycemia, allergic reactions, local injection site reactions, lipodystrophy, rash, pruritus, weight gain, and edema.[Ref]


Hypersensitivity side effects have included both local and systemic reactions. Local reactions have presented as erythema, swelling, heat, or subcutaneous nodules. They usually occurred within the first two weeks of therapy and then disappear. Systemic allergy is a generalized allergy to insulin which may present as a rash over the whole body, shortness of breath, wheezing, drop in blood pressure, fast pulse, or sweating. Severe cases may be life-threatening.

There have been rare reports of patients with hypersensitivity reactions to human insulins who have tolerated insulins of animal origin.[Ref]

Uncommon (0.1% to 1%): Local reactions such as redness, swelling, or itching at the injection site
Very rare (less than 0.01%): Systemic reactions[Ref]


Frequency not reported: Peripheral edema[Ref]

Insulin may cause sodium retention and edema, especially if previously poor metabolic control is improved by intensified insulin therapy.[Ref]


Uncommon (0.1% to 1%): Lipodystrophy
Frequency not reported: Rash, pruritus[Ref]


Very common (10% or more): Hypoglycemia[Ref]


Refraction anomalies may occur upon initiation of insulin; symptoms are usually transient. Intensification of insulin therapy may be associated with temporary worsening of diabetic retinopathy.[Ref]

Frequency not reported: Refraction anomalies, temporary worsening of diabetic retinopathy[Ref]


Injection site reactions including pain, redness, hives, inflammation, bruising, swelling, and itching, may occur. These reactions are usually transitory and may be related to factors other than insulin, such as irritants in the skin cleansing agent or poor injection technique.[Ref]

Frequency not reported: Injection site reactions[Ref]


Frequency not reported: Weight gain[Ref]

Weight gain has been attributed to the anabolic effects of insulin and the decrease in glycosuria.[Ref]


Frequency not reported: Anti-insulin antibodies[Ref]

Nervous system

Frequency not reported: Acute painful neuropathy[Ref]

Fast improvement in blood glucose has been associated with acute painful neuropathy, which is generally reversible.[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Humulin 70/30 (insulin isophane-insulin regular)." Lilly, Eli and Company, Indianapolis, IN.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

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