Injectafer Side Effects

Generic Name: ferric carboxymaltose

Note: This page contains side effects data for the generic drug ferric carboxymaltose. It is possible that some of the dosage forms included below may not apply to the brand name Injectafer.

It is possible that some side effects of Injectafer may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to ferric carboxymaltose: intravenous solution

Along with its needed effects, ferric carboxymaltose (the active ingredient contained in Injectafer) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ferric carboxymaltose:

Less common
  • Blurred vision
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • feeling of warmth
  • headache
  • nervousness
  • pounding in the ears
  • redness of the face, neck, arms, and occasionally, upper chest
  • slow or fast heartbeat
  • sweating
  • unusual tiredness or weakness
Incidence not known
  • Chest discomfort
  • chills
  • cough
  • difficult or labored breathing
  • difficulty swallowing
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • hives
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • tightness in the chest

Some side effects of ferric carboxymaltose may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Nausea
Less common
  • Change in taste
  • discoloration at the injection site
  • loss of taste
  • vomiting
  • Abdominal or stomach pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • diarrhea
  • difficulty having a bowel movement (stool)
  • pain or irritation at the injection site
  • sneezing
Incidence not known
  • Back pain
  • difficulty with moving
  • hives or welts
  • muscle pain or stiffness
  • pain in the joints
  • redness of the skin

For Healthcare Professionals

Applies to ferric carboxymaltose: intravenous solution


Common (1% to 10%): Hypertension, flushing/hot flush, hypotension
Postmarketing reports: Tachycardia, chest discomfort, angioedema


Uncommon (0.1% to 1%): Rash
Postmarketing reports: Urticaria, pruritis, erythema


Common (1% to 10%): Nausea, vomiting
Uncommon (0.1% to 1%): Constipation, abdominal pain, diarrhea


Common (1% to 10%): Blood phosphorus decrease


Common (1% to 10%): Alanine aminotransferase increase


Common (1% to 10%): Pruritus, rash, urticaria, wheezing, and hypertension associated with hypersensitivity
Rare (less than 0.1%): Serious anaphylactic/anaphylactoid reactions


Common (1% to 10%): Injection site discoloration
Uncommon (0.1% to 1%): Injection site pain/irritation


Common (1% to 10%): Hypophosphatemia
Uncommon (0.1% to 1%): Gamma glutamyl transferase increase


Postmarketing reports: Back pain, arthralgia

Nervous system

Common (1% to 10%): Dizziness, headache, dysgeusia
Uncommon (0.1% to 1%): Paraesthesia
Rare (less than 0.1%): Hypophosphatemic osteomalacia
Postmarketing reports: Syncope


Frequency not reported: Overestimate of serum iron and transferrin bound iron laboratory assays
Postmarketing reports: Pyrexia chills


Uncommon (0.1% to 1%): Sneezing
Postmarketing reports: Dyspnea

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