Injectafer Side Effects

Generic Name: ferric carboxymaltose

Note: This page contains information about the side effects of ferric carboxymaltose. Some of the dosage forms included on this document may not apply to the brand name Injectafer.

Not all side effects for Injectafer may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ferric carboxymaltose: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by ferric carboxymaltose (the active ingredient contained in Injectafer). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking ferric carboxymaltose, check with your doctor or nurse immediately:

Less common
  • Blurred vision
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • feeling of warmth
  • headache
  • nervousness
  • pounding in the ears
  • redness of the face, neck, arms, and occasionally, upper chest
  • slow or fast heartbeat
  • sweating
  • unusual tiredness or weakness
Incidence not known
  • Chest discomfort
  • chills
  • cough
  • difficult or labored breathing
  • difficulty swallowing
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • hives
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • tightness in the chest

Some of the side effects that can occur with ferric carboxymaltose may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Nausea
Less common
  • Change in taste
  • discoloration at the injection site
  • loss of taste
  • vomiting
Rare
  • Abdominal or stomach pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • diarrhea
  • difficulty having a bowel movement (stool)
  • pain or irritation at the injection site
  • sneezing
Incidence not known
  • Back pain
  • difficulty with moving
  • hives or welts
  • muscle pain or stiffness
  • pain in the joints
  • redness of the skin

For Healthcare Professionals

Applies to ferric carboxymaltose: intravenous solution

Cardiovascular

Common (1% to 10%): Hypertension, flushing/hot flush, hypotension
Uncommon (0.1% to 1%): Tachycardia, chest pain, peripheral edema
Rare (less than 0.1%): Phlebitis
Postmarketing reports: Chest discomfort, pallor

Dermatologic

Uncommon (0.1% to 1%): Rash, pruritus, urticaria, erythema
Postmarketing reports: Dermatitis

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, dysgeusia
Uncommon (0.1% to 1%): Constipation, abdominal pain, diarrhea, dyspepsia
Rare (less than 0.1%): Flatulence

Hepatic

Common (1% to 10%): Alanine aminotransferase increase
Uncommon (0.1% to 1%): Gamma glutamyl transferase increase, aspartate aminotransferase increase

Hypersensitivity

Common (1% to 10%): Pruritus, rash, urticaria, wheezing, and hypertension associated with hypersensitivity reactions
Rare (less than 0.1%): Serious anaphylactic/anaphylactoid reactions
Postmarketing reports: Angioedema

Local

Common (1% to 10%): Injection site reactions

Injection site reactions include infusion site burning, -pain, -bruising, -discoloration, -extravasation, -irritation, and -paresthesia.

Metabolic

Common (1% to 10%): Hypophosphatemia; blood phosphorus decrease
Uncommon (0.1% to 1%): Blood lactate dehydrogenase increase, blood alkaline phosphatase increase

Musculoskeletal

Postmarketing reports: Myalgia, back pain, arthralgia, muscle spasms, hypophosphatemic osteomalacia

Nervous system

Common (1% to 10%): Dizziness, headache
Uncommon (0.1% to 1%): Paraesthesia
Rare (less than 0.1%): Syncope, presyncope
Postmarketing reports: Loss of consciousness, vertigo

Other

Uncommon (0.1% to 1%): Pyrexia, fatigue, pain, chills
Rare (less than 0.1%): Malaise, rigors
Frequency not reported: Overestimate of serum iron and transferrin bound iron laboratory assays
Postmarketing reports: Face edema

Respiratory

Uncommon (0.1% to 1%): Sneezing
Rare (less than 0.1%): Bronchospasm
Postmarketing reports: Dyspnea

Psychiatric

Rare (less than 0.1%): Anxiety

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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