Hyperstat Side Effects

Generic name: diazoxide

Note: This document contains side effect information about diazoxide. Some of the dosage forms listed on this page may not apply to the brand name Hyperstat.

Some side effects of Hyperstat may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to diazoxide: oral suspension

Get emergency medical help if you have any of these signs of an allergic reaction while taking diazoxide (the active ingredient contained in Hyperstat) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• shortness of breath, swelling in your hands or feet;

• rapid pulse;

• fast or pounding heartbeats;

• chest pain;

• blurred vision, eye pain, or seeing halos around lights;

• easy bruising or bleeding, unusual weakness;

• fever, chills, body aches, flu symptoms;

• urinating less than usual; or

• feeling like you might pass out.

Less serious side effects of diazoxide may include:

• temporary increase in growth of body hair (especially in women and children;

• nausea, vomiting, stomach pain, loss of appetite;

• diarrhea;

• decreased sense of taste;

• headache, dizziness, anxiety;

• weakness; or

• mild itching or skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

For Healthcare Professionals

Applies to diazoxide: compounding powder, injectable solution, oral capsule, oral suspension

General

The most common reactions reported following diazoxide (the active ingredient contained in Hyperstat) administration include hypotension (7%), nausea and vomiting (4%), dizziness and weakness (2%).

Cardiovascular

Cardiovascular effects including sodium and water retention following repeated injections, hypotension, shock, myocardial ischemia, myocardial and cerebral infarction, angina, atrial and ventricular arrhythmias, marked electrocardiographic changes, optic nerve infarction, supraventricular tachycardia and palpitation, bradycardia, and chest discomfort have been reported.

Angina with myocardial and cerebral infarction have been associated with the use of a 300 mg intravenous dose of diazoxide.

One case of optic nerve infarction was reported following a single 300 mg bolus dose of diazoxide, as a result of a sudden reduction in diastolic pressure.

Results from one prospective trial conducted in patients with severe hypertension and coronary artery disease showed a 50% incidence of ischemic changes in the electrocardiogram following single 300 mg bolus injections of diazoxide.

Nervous system

Nervous system affects reported following diazoxide (the active ingredient contained in Hyperstat) administration include cerebral ischemia, convulsions, paralysis, confusion, numbness of the hands, orthostatic hypotension, sweating, flushing, generalized or localized sensations of warmth, headache, dizziness, lightheadedness, sleepiness, lethargy, somnolence, drowsiness, euphoria, tinnitus, momentary loss of hearing, weakness and anxiety.

Gastrointestinal

Gastrointestinal side effects have been rarely reported and include acute pancreatitis, nausea, vomiting, abdominal discomfort, anorexia, alteration in taste, parotid swelling, salivation, dry mouth, lacrimation, ileus, constipation and diarrhea.

Metabolic

Metabolic effects including hyperglycemia have been reported in diabetic and nondiabetic patients, especially after repeated injections. Transient retention of nitrogenous wastes has also been reported.

Respiratory

Respiratory effects including dyspnea, cough and choking sensation have been reported.

Hypersensitivity

Hypersensitivity reactions characterized by rash, leukopenia, fever and papilledema induced by plasma volume expansion secondary to the administration of diazoxide (the active ingredient contained in Hyperstat) have been reported.

Other

Other effects including warmth or pain along the injected vein, cellulitis and/or phlebitis at the injection site of extravasation, back pain, increased nocturia, malaise, blurred vision, hirsutism, and decreased libido have been reported.

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