Hyperstat Side Effects
Generic Name: diazoxide
Note: This page contains information about the side effects of diazoxide. Some of the dosage forms included on this document may not apply to the brand name Hyperstat.
Not all side effects for Hyperstat may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to diazoxide: oral capsule, oral suspension
In addition to its needed effects, some unwanted effects may be caused by diazoxide (the active ingredient contained in Hyperstat). In the event that any of these side effects do occur, they may require medical attention.
Stop taking diazoxide and get emergency help immediately if any of the following effects occur:Rare
- Chest pain caused by exercise or activity
- numbness of the hands
- shortness of breath (unexplained)
If any of the following side effects occur while taking diazoxide, check with your doctor or nurse as soon as possible:More common
- Decreased urination
- swelling of feet or lower legs
- weight gain (rapid)
- Fast heartbeat
- skin rash
- stiffness of arms or legs
- trembling and shaking of hands and fingers
- unusual bleeding or bruising
Some of the side effects that can occur with diazoxide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:Less common
- Changes in ability to taste
- increased hair growth on forehead, back, arms, and legs
- loss of appetite
- nausea and vomiting
- stomach pain
This medicine may cause a temporary increase in hair growth in some people when it is used for a long time. After treatment with diazoxide has ended, normal hair growth should return.
For Healthcare Professionals
Applies to diazoxide: compounding powder, injectable solution, oral capsule, oral suspension
The most common reactions reported following diazoxide (the active ingredient contained in Hyperstat) administration include hypotension (7%), nausea and vomiting (4%), dizziness and weakness (2%).[Ref]
Cardiovascular effects including sodium and water retention following repeated injections, hypotension, shock, myocardial ischemia, myocardial and cerebral infarction, angina, atrial and ventricular arrhythmias, marked electrocardiographic changes, optic nerve infarction, supraventricular tachycardia and palpitation, bradycardia, and chest discomfort have been reported.[Ref]
Angina with myocardial and cerebral infarction have been associated with the use of a 300 mg intravenous dose of diazoxide.
One case of optic nerve infarction was reported following a single 300 mg bolus dose of diazoxide, as a result of a sudden reduction in diastolic pressure.
Results from one prospective trial conducted in patients with severe hypertension and coronary artery disease showed a 50% incidence of ischemic changes in the electrocardiogram following single 300 mg bolus injections of diazoxide.[Ref]
Nervous system affects reported following diazoxide (the active ingredient contained in Hyperstat) administration include cerebral ischemia, convulsions, paralysis, confusion, numbness of the hands, orthostatic hypotension, sweating, flushing, generalized or localized sensations of warmth, headache, dizziness, lightheadedness, sleepiness, lethargy, somnolence, drowsiness, euphoria, tinnitus, momentary loss of hearing, weakness and anxiety.[Ref]
Gastrointestinal side effects have been rarely reported and include acute pancreatitis, nausea, vomiting, abdominal discomfort, anorexia, alteration in taste, parotid swelling, salivation, dry mouth, lacrimation, ileus, constipation and diarrhea.[Ref]
Metabolic effects including hyperglycemia have been reported in diabetic and nondiabetic patients, especially after repeated injections. Transient retention of nitrogenous wastes has also been reported.[Ref]
Respiratory effects including dyspnea, cough and choking sensation have been reported.[Ref]
Hypersensitivity reactions characterized by rash, leukopenia, fever and papilledema induced by plasma volume expansion secondary to the administration of diazoxide (the active ingredient contained in Hyperstat) have been reported.[Ref]
Other effects including warmth or pain along the injected vein, cellulitis and/or phlebitis at the injection site of extravasation, back pain, increased nocturia, malaise, blurred vision, hirsutism, and decreased libido have been reported.[Ref]
1. "Product Information. Hyperstat I.V. (diazoxide)." Schering Corp, Kenilworth, NJ.
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