Hydrocortisone rectal Side Effects
Please note - some side effects for Hydrocortisone rectal may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects by Body System - for Healthcare Professionals
Applies to: compounding powder; rectal cream with applicator; rectal ointment; rectal suppository; topical cream; topical gel; topical kit; topical lotion; topical ointment; topical pad; topical paste; topical solution; topical spray; topical stick
Endocrine side effects of topical corticosteroids are rare. Glucose intolerance and hyperglycemia may be induced by corticosteroids. These drugs can rarely suppress the hypothalamic-pituitary-adrenal axis. This suppression is more likely when higher potency topical steroids are used over extensive areas and when occlusive dressings are used.
Local adverse effects of hydrocortisone application may commonly include burning, itching, or irritation, especially if applied to denuded skin or with occlusive dressings. Long-term use of topical corticosteroids may result in skin atrophy and thinning, and the development of striae, telangiectasia, subcutaneous hemorrhage, and easy bruising and bleeding. Allergic contact dermatitis is occasionally reported.
Skin on the face, axillae, and groin appear to be most susceptible to the adverse, long-term effects of topical steroids.
Topical corticosteroid use may inhibit local immune response rendering the skin more susceptible to infections. Folliculitis has occasionally been reported.
Perioral dermatitis or rosacea-like dermatitis has occurred in patients treated with potent topical corticosteroids who are of seborrheic skin type. This condition may flare temporarily upon discontinuation of topical steroids, prompting patients to continue their use. If topical corticosteroids are discontinued, this flare and the initial dermatitis generally resolves over a few weeks.
Gastrointestinal side effects of rectally administered hydrocortisone include diarrhea, cramps, flatulence, rectal irritation, and rectal bleeding.
Musculoskeletal side effects from rectal administration may include muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humeral heads, and pathologic fracture of long bones.Top
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