Histussin D Side Effects
Generic Name: hydrocodone / pseudoephedrine
Note: This page contains information about the side effects of hydrocodone / pseudoephedrine. Some of the dosage forms included on this document may not apply to the brand name Histussin D.
Not all side effects for Histussin D may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to hydrocodone / pseudoephedrine: oral liquid, oral solution, oral syrup, oral tablet
In addition to its needed effects, some unwanted effects may be caused by hydrocodone / pseudoephedrine. In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking hydrocodone / pseudoephedrine:More common
- Blurred vision
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, slow, or irregular heartbeat
- unusual tiredness or weakness
- Abdominal or stomach cramps or pain
- bulging soft spot on the head of an infant
- change in the ability to see colors, especially blue or yellow
- decrease in the frequency of urination
- decrease in urine volume
- difficult or painful urination
- difficult or troubled breathing
- difficulty having a bowel movement (stool)
- difficulty in passing urine (dribbling)
- frequent urge to urinate
- irregular, fast or slow, or shallow breathing
- loss of appetite
- pale or blue lips, fingernails, or skin
- pounding in the ears
- shakiness in the legs, arms, hands, or feet
- shortness of breath
- trembling or shaking of the hands or feet
- trouble with sleeping
- unable to sleep
Some of the side effects that can occur with hydrocodone / pseudoephedrine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common
- mood changes
- relaxed and calm
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- Itching skin
- skin rash
For Healthcare Professionals
Applies to hydrocodone / pseudoephedrine: oral liquid, oral liquid extended release, oral syrup, oral tablet
Opioids may result in psychotic symptoms in some patients.
Nervous system side effects of hydrocodone have included mental and respiratory depression, stupor, delirium, somnolence, and dysphoria. Nervous system side effects of pseudoephedrine have included insomnia in up to 30% of patients. Tremor, anxiety, nervousness, and headache have also been reported.
Other side effects of hydrocodone have included withdrawal symptoms, such as agitation, restlessness, anxiety, insomnia, tremor, abdominal cramps, blurred vision, vomiting and sweating, after either abrupt cessation or fast tapering of narcotic analgesics.
Gastrointestinal side effects of hydrocodone have included nausea, vomiting, constipation, and dry mouth. Gastrointestinal side effects of pseudoephedrine have included anorexia and gastric irritation in approximately 5% of patients. Dry mouth, nose, or throat have occurred in up to 15% of patients.
Cardiovascular side effects of pseudoephedrine have included tachycardia. Some patients have developed hypertension and/or arrhythmias.
Pseudoephedrine causes vasoconstriction which generally does not produce hypertension, but may be problematic for patients with preexisting hypertension. Arrhythmias may be produced in predisposed patients. Rarely, pseudoephedrine has been reported to cause coronary artery spasm and chest pain.
One report evaluated the effect with 60 mg of pseudoephedrine on individuals in a hyperbaric chamber at 1 atmosphere (simulated scuba dive to 66 feet of sea water). Pseudoephedrine and depth (simulated) were found to have significant but opposite effects on heart rate, although these effects were unlikely to be clinically significant during diving.
Genitourinary side effects of hydrocodone have included ureteral spasm, spasm of vesicle sphincters, and urinary retention.
Dermatologic side effects of hydrocodone have included rash.
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