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Guanabenz Side Effects

Not all side effects for guanabenz may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to guanabenz: oral tablet

In addition to its needed effects, some unwanted effects may be caused by guanabenz. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking guanabenz, check with your doctor or nurse as soon as possible:

Signs and symptoms of overdose
  • Dizziness (severe)
  • irritability
  • nervousness
  • pinpoint pupils
  • slow heartbeat
  • unusual tiredness or weakness

Some of the side effects that can occur with guanabenz may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Dizziness
  • drowsiness
  • dryness of mouth
  • weakness
Less common or rare
  • Decreased sexual ability
  • headache
  • nausea

After you stop taking this drug, it is possible that you may still experience side effects that need medical attention. If you notice any of the following side effects check with your doctor immediately:

  • Anxiety or tenseness
  • chest pain
  • fast or irregular heartbeat
  • headache
  • increased salivation
  • increase in sweating
  • nausea or vomiting
  • nervousness or restlessness
  • shaking or trembling of hands or fingers
  • stomach cramps
  • trouble in sleeping

For Healthcare Professionals

Applies to guanabenz: compounding powder, oral tablet

Other

In comparative studies the overall incidence of side effects associated with guanabenz was as high or higher than that seen with methyldopa or clonidine, but particularly troublesome effects, such as sodium retention, mental depression or sexual dysfunction, which have been associated with these drugs, have not been associated with guanabenz.

Nervous system

The most common side effects involve the nervous system. Drowsiness is a complaint in up to 35% of patients, and, with dry mouth, is the main reason some patients discontinue therapy. Weakness or dizziness each occur in 6% and headache in 2% in patients.

Gastrointestinal

Gastrointestinal side effects include dry mouth in up to 37%, constipation in 2%, and nausea in 1% of patients.

Cardiovascular

Postural hypotension may not have been observed, at least during initial therapy with guanabenz, due to peripheral vascular resistance and cardiac output remaining unchanged.

Although usually asymptomatic, guanabenz can decrease heart rate. Other cardiovascular side effects are rare. Unlike some other alpha-2-adrenoreceptor agonists, guanabenz is only rarely associated with orthostatic hypotension. Rebound hypertension can be a significant problem that may be accompanied by nervousness, palpitations, diaphoresis, anxiety, insomnia, malaise, and abdominal cramps. It has been observed anywhere from 16 to 72 hours after discontinuation of therapy.

Respiratory

Nasal congestion has been reported in less than 3% of patients.

Dermatologic

Dermatologic rashes have been reported in less than 3% of patients.

Ocular

Ocular side effects are limited to rare cases of blurry vision.

Endocrine

There are no serious endocrinologic side effects associated with guanabenz. The drug does not appear to adversely affect the lipid profile. Some data indicate significant decreases in total and LDL cholesterol levels during guanabenz therapy.

Renal

There are no known clinically significant renal side effects from guanabenz. Acutely (within the first day of therapy), guanabenz may cause a mild water diuresis. Unlike some alpha-2-adrenoreceptor agonists, guanabenz is not associated with sodium and water retention.

Some data have shown significant increases in glomerular filtration rate, natriuresis, and free water clearance associated with the use of guanabenz during the first few hours of therapy. Use of guanabenz for one week or more, however, has not been associated with significant changes in renal function parameters.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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