Guaifenesin / hydrocodone Side Effects
Not all side effects for guaifenesin / hydrocodone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to guaifenesin / hydrocodone: liquid, sustained-release tablets, syrup, tablets
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking guaifenesin / hydrocodone:
Constipation; dizziness; drowsiness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; change in amount of urine; difficulty urinating; hearing change or loss; mental or mood changes; severe drowsiness.
For Healthcare Professionals
Applies to guaifenesin / hydrocodone: oral capsule, oral liquid, oral syrup, oral tablet, oral tablet extended release
One study has suggested that the respiratory depression caused by hydrocodone may be of benefit in the treatment of dyspnea related to chronic obstructive pulmonary disease and restrictive lung disease. However, the potential for the precipitation of respiratory insufficiency makes such use of hydrocodone hazardous and such use should be undertaken, if at all, only with extreme caution.
Nervous system side effects of guaifenesin have included dizziness and headache. Central nervous system adverse effects of hydrocodone have included mental depression, dizziness, lightheadedness, respiratory depression (which is sometimes fatal), stupor, delirium, somnolence, agitation, and dysphoria.
Other side effects of hydrocodone have included withdrawal symptoms, such as agitation, restlessness, anxiety, insomnia, tremor, abdominal cramps, blurred vision, vomiting and sweating, after either abrupt cessation or fast tapering of narcotic analgesics.
Gastrointestinal side effects of guaifenesin have included upset stomach and vomiting with higher than recommended doses. Doses recommended for expectoration are rarely associated with gastrointestinal upset. Gastrointestinal side effects of hydrocodone have included nausea, vomiting, constipation, and dry mouth.
Genitourinary side effects of hydrocodone have included ureteral spasm, spasm of vesicle sphincters, and urinary retention.
Dermatologic side effects of guaifenesin have included rash. Narcotic-induced rash has also been reported.
More about guaifenesin/hydrocodone
- Guaifenesin/hydrocodone liquid
- Guaifenesin/hydrocodone sustained-release tablets
- Guaifenesin and hydrocodone
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