Grifulvin V Tablets Side Effects
Please note - some side effects for Grifulvin V Tablets may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects by Body System - for Healthcare Professionals
Applies to: compounding powder; oral capsule; oral suspension; oral tablet
Hypersensitivity side effects have been reported most commonly. These have included skin rashes, urticaria, erythema multiforme-like drug reactions, and rarely, angioneurotic edema.
Fixed-drug eruptions have been verified by rechallenge.
At least one reported case of toxic epidermal necrolysis resulted in death.
At least one fatal case of SLE exacerbation occurred after ingestion of approximately 1 gram of griseofulvin.
Dermatologic side effects have included severe skin reactions (including Stevens-Johnson syndrome and toxic epidermal necrolysis) and erythema multiforme. Fixed-drug eruptions, photosensitivity, exacerbation of systemic lupus erythematosus (SLE), and SLE-like syndromes have been reported. A patient with Hailey-Hailey disease (chronic benign familial pemphigus) experienced a widespread bullous eruption due to griseofulvin therapy. Lesions have commonly begun on sun-exposed areas.
Neuropathy and paresthesia have been reported in a few cases of long-term griseofulvin therapy. One woman reportedly developed paresthesia in the fingers and feet after 6 months of griseofulvin therapy. Neuropathy progressed for 4 months after the drug was discontinued but resolved 8 months after therapy was discontinued.
Nervous system side effects have included headache, insomnia, dizziness, and mental confusion. Neuropathy and development of paresthesia of the hands and feet have been reported with long-term use.
Hepatic side effects have included hepatotoxicity, jaundice, and elevations in AST, ALT, and bilirubin.
Gastrointestinal side effects have included nausea, vomiting, epigastric/abdominal distress, and oral thrush.
One patient developed interstitial nephritis after one year of griseofulvin therapy. The patient presented with renal insufficiency, hematuria, pyuria, eosinophiluria, and anemia. Renal function returned to normal after one year.
Renal side effects have included interstitial nephritis.
Genitourinary side effects have included proteinuria and menstrual irregularities.
Hematologic side effects have included leukopenia.
Metabolic side effects have included exacerbation of porphyria.
A disulfiram-like reaction, including flushing, nausea, vomiting, diarrhea and paresthesia of the extremities, occurred in one patient who ingested griseofulvin with alcohol.
Other side effects have included fever, fatigue, and a disulfiram-like reaction. Impairment of performance of routine activities has been reported occasionally.
Musculoskeletal side effects have included at least one case of griseofulvin-induced myositis.Top
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