Glyset Side Effects
Generic Name: miglitol
Note: This page contains information about the side effects of miglitol. Some of the dosage forms included on this document may not apply to the brand name Glyset.
Not all side effects for Glyset may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to miglitol: oral tablet
Some of the side effects that can occur with miglitol (the active ingredient contained in Glyset) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common
- Bloated full feeling
- excess air or gas in stomach or intestines
- increase in bowel movements
- loose stools
- passing gas
- soft stools
- stomach or abdomen pain
- Skin rash
For Healthcare Professionals
Applies to miglitol: oral tablet
Very common (10% or more): Flatulence (41.5%), diarrhea (28.7%), abdominal pain (11.7%)
Postmarketing reports: Pneumatosis cystoides intestinalis (may present with symptoms of diarrhea, mucus discharge, rectal bleeding, and constipation), ileus (including paralytic ileus), subileus, gastrointestinal pain, nausea, abdominal distention.[Ref]
The severity of gastrointestinal symptoms may be decreased by dosage reduction and avoiding high gas-producing foods and sucrose. Some studies have demonstrated a decrease in the severity of gastrointestinal effects over time with continued administration.[Ref]
Common (1% to 10%): Skin rash (4.3%)[Ref]
Common (1% to 10%): Low serum iron (9.2%)[Ref]
1. Lembcke B, Diederich M, Folsch UR, Creutzfeldt W "Postprandial glycemic control, hormonal effects and carbohydrate malabsorption during long-term administration of the alpha- glucosidase inhibitor miglitol." Digestion 47 (1990): 47-55
2. "Product Information. Glyset (miglitol)." Bayer, West Haven, CT.
3. Heinz G, Komjati M, Korn A, Waldhausl W "Reduction of postprandial blood glucose by the alpha-glucosidase inhibitor Miglitol (BAY m 1099) in type II diabetes." Eur J Clin Pharmacol 37 (1989): 33-6
4. Johnston PS, Coniff RF, Hoogwerf BJ, Santiago JV, Pi-Sunyer FX, Krol A "Effects of the carbohydrase inhibitor miglitol in sulfonylurea- treated NIDDM patients." Diabetes Care 17 (1994): 20-9
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