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Geodon Side Effects

Generic Name: ziprasidone

Note: This page contains information about the side effects of ziprasidone. Some of the dosage forms included on this document may not apply to the brand name Geodon.

Not all side effects for Geodon may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ziprasidone: oral capsule

In addition to its needed effects, some unwanted effects may be caused by ziprasidone (the active ingredient contained in Geodon). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking ziprasidone:

More common
  • Cough
  • difficulty with speaking
  • drooling
  • fear or nervousness
  • fever
  • inability to sit still
  • loss of balance control
  • muscle trembling, jerking, or stiffness
  • need to keep moving
  • restlessness
  • shuffling walk
  • sneezing
  • sore throat
  • stiffness of the limbs
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
Less common
  • Blurred vision
  • body aches or pain
  • chest pain
  • congestion
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • headache
  • hoarseness
  • pounding in the ears
  • runny nose
  • slow or fast heartbeat
  • swelling of the tongue
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes
Rare
  • Fainting or feeling faint
  • feeling faint upon standing
  • persistent, painful erection
  • seizures
Incidence not known
  • Inability to move the eyes
  • increased blinking or spasms of the eyelid
  • sticking out of tongue
  • trouble with breathing, speaking, or swallowing
  • uncontrolled twisting movements of the neck, trunk, arms, or legs
  • unusual facial expressions

If any of the following symptoms of overdose occur while taking ziprasidone, get emergency help immediately:

Symptoms of overdose
  • Drowsiness
  • shakiness in the legs, arms, hands, or feet
  • sleepiness
  • slurred speech
  • trembling or shaking of the hands or feet

Some of the side effects that can occur with ziprasidone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Acid or sour stomach
  • belching
  • constipation
  • diarrhea
  • heartburn
  • indigestion
  • lack or loss of strength
  • nausea
  • rash
  • stomach discomfort, upset, or pain
  • weakness
  • weight gain
Less common
  • Blistering, crusting, irritation, itching, or reddening of the skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in vision
  • cracked, dry, or scaly skin
  • depression
  • difficulty with moving
  • dry mouth
  • increase in salivation
  • itching or reddening of the skin
  • joint pain
  • loss of appetite
  • muscle ache
  • muscle pains or stiffness
  • muscle tightness
  • stuffy nose
  • swelling
  • swollen joints
  • vomiting
  • weakness of the arms and legs
  • weight loss

For Healthcare Professionals

Applies to ziprasidone: intramuscular powder for injection, oral capsule

General

The most commonly reported adverse events included somnolence, respiratory tract infections, extrapyramidal symptoms, dizziness, akathisia, abnormal vision, asthenia, vomiting, headache, and nausea.[Ref]

Metabolic

Uncommon (0.1% to 1%): Thirst, increased appetite, hypercholesteremia, dehydration, hyperglycemia, hypokalemia
Rare (less than 0.1%): Hypocalcemia, hyperlipidemia, hyperkalemia, hypochloremia, hypoglycemia, hyponatremia, hypoproteinemia, gout, hyperchloremia, hyperuricemia, hypomagnesemia, ketosis[Ref]

Weight gain of 7% or more was statistically significantly greater among patients with schizophrenia receiving ziprasidone in a pooled analysis of four 4 and 6 week placebo-controlled trials (10% versus 4%). The median weight gain was 0.5 kg among all ziprasidone patients compared with no weight gain in the placebo patients.[Ref]

Nervous system

Very common (10% or more): Headache (18%), extrapyramidal symptoms (31%), somnolence (14%)
Common (1% to 10%): Akathisia, dizziness, dyskinesia, dystonia, headache, sedation, tremor, hypertonia, speech disorder
Uncommon (0.1% to 1%): Ataxia, bradykinesia, cogwheel rigidity, disturbance in attention, dizziness postural, drooling, dysarthria, generalized tonic-clonic seizures, hyperkinesia, hypersomnia, hypoesthesia, lethargy, oculogyric crisis, paresthesia, tardive dyskinesia, amnesia, buccoglossal syndrome, choreoathetosis, diplopia, incoordination, neuropathy
Rare (less than 0.1%): Akinesis, paresis, restless legs syndrome, torticollis, paralysis
Postmarketing reports: Facial droop, neuroleptic malignant syndrome, serotonin syndrome (alone or in combination with serotonergic products), tardive dyskinesia[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, dry mouth, nausea, thick tongue, vomiting, dyspepsia, diarrhea, anorexia
Uncommon (0.1% to 1%): Gastrointestinal discomfort, salivary hypersecretion, dysphagia, flatulence, gastritis, rectal hemorrhage, tongue edema
Rare (less than 0.1%): Gastroesophageal reflux, loose stools, gum hemorrhage, fecal impaction, hematemesis, leukoplakia of mouth, melena
Postmarketing reports: Dysphagia, swollen tongue[Ref]

Respiratory

Common (1% to 10%): Respiratory tract infection, increased cough, rhinitis
Uncommon (0.1% to 1%): Dyspnea, sore throat, pneumonia, epistaxis
Rare (less than 0.1%): Hiccups, hemoptysis, laryngismus[Ref]

Collective data gathered from 17 placebo-controlled clinical studies (n=5106) involving the use of atypical antipsychotic agents for the treatment of behavioral disorders in the elderly patient with dementia showed a risk of death 1.6 to 1.7 times greater in the drug-treated patient than in the placebo-treated patient. The average length of duration for the trials was 10 weeks with the cause of death in the majority of cases, though not all, reported as either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Although ziprasidone was not included in these studies, the consistent findings across all three relevant chemical classes support the opinion that these findings are likely to be applicable to all atypical antipsychotic agents. Ziprasidone is not approved by the FDA for use in the treatment of behavioral disorders in elderly patients with dementia.[Ref]

Cardiovascular

Collective data gathered from 17 placebo-controlled clinical studies (n=5106) involving the use of atypical antipsychotic agents for the treatment of behavioral disorders in the elderly patient with dementia showed a risk of death 1.6 to 1.7 times greater in the drug-treated patient than in the placebo-treated patient. The average length of duration for the trials was 10 weeks with the cause of death in the majority of cases, though not all, reported as either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Although ziprasidone (the active ingredient contained in Geodon) was not included in these studies, the consistent findings across all three relevant chemical classes support the opinion that these findings are likely to be applicable to all atypical antipsychotic agents. Ziprasidone is not indicated for use in the treatment of behavioral disorders in elderly patients with dementia.

In a study evaluating the QT prolonging effect of oral ziprasidone with other drugs used in the treatment of schizophrenia, the mean increase in QTc from baseline ranged from 9 to 14 seconds which was greater than 4 of the comparator drugs (risperidone, olanzapine, quetiapine, and haloperidol) but was approximately 14 seconds less than thioridazine.[Ref]

Common (1% to 10%): Chest pain, tachycardia, postural hypotension, hypertension
Uncommon (0.1% to 1%): Right bundle branch block, palpitation, bradycardia, angina pectoris, atrial fibrillation, peripheral edema
Rare (less than 0.1%): ECG QTc prolonged, increased pulse, first degree AV block, bundle branch block, phlebitis, pulmonary embolism, cardiomegaly, cerebral infarct, cerebrovascular accident, deep thrombophlebitis, myocarditis, thrombophlebitis
Postmarketing reports: Torsades de pointes, postural hypotension, hypotension, syncope, venous thromboembolism[Ref]

Hypersensitivity

Postmarketing reports: Allergic reaction[Ref]

Dermatologic

Common (1% to 10%): Rash, fungal dermatitis, face edema, photosensitivity reaction, sweating
Uncommon (0.1% to 1%): Acne, maculopapular rash, urticaria, eczema, exfoliative dermatitis, vesiculobullous rash
Rare (less than 0.1%): Alopecia, dermatitis allergic, erythema, psoriasis, skin irritation, swelling face, rash papular
Postmarketing reports: Angioedema, rash, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)[Ref]

Psychiatric

Common (1% to 10%): Restlessness, insomnia, agitation
Uncommon (0.1% to 1%): Anxiety, throat tightness, nightmare
Rare (less than 0.1%): Anorgasmia, bradyphrenia, flat affect, panic attack, sleep walking
Postmarketing reports: Mania/hypomania[Ref]

Ocular

Common (1% to 10%): Blurred vision, abnormal vision
Uncommon (0.1% to 1%): Photophobia, conjunctivitis, dry eyes, blepharitis, cataract
Rare (less than 0.1%): Amblyopia, eye pruritus, visual disturbance, eye hemorrhage, visual field defect, keratitis, keratoconjunctivitis[Ref]

Endocrine

Uncommon (0.1% to 1%): Impotence, abnormal ejaculation, female lactation,
Rare (less than 0.1%): Erectile dysfunction, increased erection, galactorrhea, gynecomastia, hypothyroidism, hyperthyroidism, thyroiditis, female sexual dysfunction
Postmarketing reports: Priapism[Ref]

Musculoskeletal

Common (1% to 10%): Musculoskeletal stiffness, myalgia
Uncommon (0.1% to 1%): Joint stiffness, muscle cramps, extremity pain, tenosynovitis
Rare (less than 0.1%): Arthropathy, musculoskeletal discomfort, trismus, myopathy[Ref]

Genitourinary

Uncommon (0.1% to 1%): Dysuria, urinary incontinence, amenorrhea, hematuria, menorrhagia, polyuria, urinary retention metrorrhagia
Rare (less than 0.1%): vaginal hemorrhage, nocturia, oliguria, uterine hemorrhage
Postmarketing reports: Enuresis, urinary incontinence[Ref]

Hematologic

Uncommon (0.1% to 1%): Anemia, ecchymosis, leukocytosis, leukopenia, eosinophilia, lymphadenopathy
Rare (less than 0.1%): Lymphopenia, increased eosinophil count, abnormal eosinophil count, thrombocytopenia, hypochromic anemia, lymphocytosis, monocytosis, basophilia, lymphedema, polycythemia, thrombocythemia[Ref]

Hepatic

Uncommon (0.1% to 1%): Hepatic enzyme increased, alkaline phosphatase increased, Rare (less than 0.1%): Abnormal liver function test, jaundice, gamma glutamyl transpeptidase increased, cholestatic jaundice, hepatitis, hepatomegaly, fatty liver deposit[Ref]

Other

Common (1% to 10%): Asthenia, accidental injury, fatigue, fever, chills, hypothermia
Uncommon (0.1% to 1%): Abnormal gait, tinnitus
Rare (less than 0.1%): Ear pain, vertigo positional, body temperature increased[Ref]

Local

Local side effects associated with intramuscular ziprasidone (the active ingredient contained in Geodon) have frequently included pain at the injection site.[Ref]

Immunologic

Common (1% to 10%): Flu syndrome[Ref]

References

1. "Product Information. Geodon (ziprasidone)." Pfizer US Pharmaceuticals, New York, NY.

2. Cerner Multum, Inc. "Australian Product Information." O 0

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