Gadoteridol Side Effects

Not all side effects for gadoteridol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to gadoteridol: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by gadoteridol. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking gadoteridol, check with your doctor or nurse immediately:

Rare
  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • confusion
  • cough
  • decreased awareness or responsiveness
  • difficult or labored breathing
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • feeling of warmth
  • fever
  • general feeling of discomfort or illness
  • headache
  • hives
  • hoarseness
  • increased salivation
  • itching
  • loss of bladder control
  • loss of consciousness
  • low blood pressure or pulse
  • nervousness
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the face, neck, arms, and occasionally, upper chest
  • seizures
  • shakiness in the legs, arms, hands, or feet
  • skin rash
  • slow, fast, or irregular breathing
  • spasm of the throat
  • sweating
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • unconsciousness
  • unusual tiredness or weakness

Some of the side effects that can occur with gadoteridol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Bad, unusual, or unpleasant (after) taste
  • nausea
Rare
  • Abdominal or stomach cramps
  • anxiety
  • bleeding gums
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • continuing ringing or buzzing or other unexplained noise in the ears
  • diarrhea
  • dry mouth
  • hearing loss
  • irritation in the mouth
  • loss of coordination in the arms
  • mouth ulcers
  • rash with flat lesions or small raised lesions on the skin
  • redness and swelling of the gums
  • runny nose
  • sneezing
  • stuffy nose
  • tingling sensation in the throat
  • voice changes
  • vomiting
  • watery eyes

For Healthcare Professionals

Applies to gadoteridol: injectable solution

Cardiovascular

Cardiovascular side effects have included prolonged P-R Interval, hypotension, elevated heart rate, A-V nodal rhythm, cardiac arrest, bradycardia, hypertension, and death in association with pre-existing cardiovascular disorders.[Ref]

Respiratory

Respiratory side effects have included dyspnea, rhinitis, cough, apnea, and wheezing.[Ref]

Other

Other side effects have included voice alteration; transitory deafness and tinnitus.[Ref]

Nervous system

Nervous system side effects have included headache, anxiety, dizziness, paresthesia, mental status decline, loss of coordination in arm, staring episodes, seizure, syncope, stupor, tremor, tingling sensation in extremities and digits, and loss of consciousness.[Ref]

Hypersensitivity

Hypersensitivity side effects have included anaphylactoid reactions rarely resulting in death.[Ref]

Dermatologic

Dermatologic side effects have included pruritus, rash, macular papular rash, urticaria, hives, itching, sweating, and cyanosis.[Ref]

Gastrointestinal

Gastrointestinal side effects have included edematous and/or itching tongue, gingivitis dry mouth, loose bowel, vomiting, abdominal cramps, increased salivation, and dysphagia.[Ref]

General

General side effects have included facial edema, neck rigidity, pain, chest pain, fever, tingling sensation in throat, laryngismus, flushed feeling, vasovagal reaction, and generalized edema.[Ref]

Genitourinary

Genitourinary side effects have included urinary incontinence.[Ref]

Local

Local side effects have included pain at injection site and injection site reaction.[Ref]

Ocular

Ocular side effects have included watery eyes.

References

1. "Product Information. ProHance (gadoteridol)." Bracco Diagnostics Inc, Plainsboro, NJ.

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