Gadobenate dimeglumine Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 4, 2023.

Applies to gadobenate dimeglumine: intravenous solution.

Warning

Intravenous route (Solution)

Nephrogenic Systemic Fibrosis (NSF)Gadolinium-based contrast agents (GBCAs) increase the risk for NSF among patients with impaired elimination of the drugs. Avoid use of GBCAs in these patients unless the diagnostic information is essential and not available with non-contrasted MRI or other modalities. NSF may result in fatal or debilitating systemic fibrosis affecting the skin, muscle and internal organs.The risk for NSF appears highest among patients with chronic, severe kidney disease (GFR less than 30 mL/min/1.73 m(2)) or acute kidney injury.Screen patients for acute kidney injury and other conditions that may reduce renal function. For patients at risk for chronically reduced renal function (eg, age greater than 60 years, hypertension or diabetes), estimate the glomerular filtration rate (GFR) through laboratory testing.For patients at highest risk for NSF, do not exceed the recommended gadobenate dimeglumine dose and allow a sufficient period of time for elimination of the drug from the body prior to re-administration

Serious side effects

Along with its needed effects, gadobenate dimeglumine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking gadobenate dimeglumine:

Rare

Anxiety
back pain
black, tarry stools
bladder pain
bloody or cloudy urine
blue lips and fingernails
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain or discomfort
chills
confusion
cough
coughing that sometimes produces a pink frothy sputum
dark urine
decreased urination
deep or fast breathing with dizziness
difficult or labored breathing
difficult, burning, or painful urination
difficult, fast, or noisy breathing
difficulty with breathing or swallowing
dizziness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
excessive muscle tone
fainting
fast, slow, or irregular heartbeat
fever
frequent urge to urinate
general feeling of discomfort or illness
headache
hives, itching, skin rash
inability to move the legs or arms
increased sweating
lower back or side pain
muscle stiffness, tension, or tightness
nausea
nervousness
numbness of the feet, hands, and around the mouth
pain in the shoulders, arms, jaw, or neck
pain or redness at the injection site
pale skin at the injection site
paralysis of one side of the body
pounding heartbeat
pounding in the ears
problems with speech or speaking
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
reddening of the skin, especially around the ears
seizures
shakiness in the legs, arms, hands, or feet
sore throat
sores, ulcers, or white spots on the lips or in the mouth
sugar in the urine
sweating
swelling in the legs and ankles
swelling of the eyes, face, or inside of the nose
swollen glands
tightness in the chest
tiredness
trembling or shaking of the hands or feet
unusual bleeding or bruising
unusual tiredness or weakness
yellow eyes or skin

Incidence not known

Lack or loss of strength
loss of consciousness
peeling of the skin
skin lesions

Other side effects

Some side effects of gadobenate dimeglumine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, rash, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
feeling hot

Rare

Bad, unusual, or unpleasant (after) taste
belching
blurred or loss of vision
change in sense of smell
change in taste
continuing ringing or buzzing or other unexplained noise in the ears
decreased awareness or responsiveness
diarrhea
difficulty having a bowel movement
difficulty with moving
disturbed color perception
double vision
dry mouth
ear pain
feeling unusually cold
halos around lights
hearing loss
heartburn
indigestion
joint pain
lack or loss of strength
loss of bowel control
muscle aches, spasms, or cramps
night blindness
overbright appearance of lights
redness of the eye
severe sleepiness
shivering
stomach discomfort or upset
stuffy nose
swollen joints
tunnel vision
vomiting

For Healthcare Professionals

Applies to gadobenate dimeglumine: intravenous solution.

Cardiovascular

Cardiovascular side effects have included hypertension, vasodilatation, and tachycardia.^[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, and diarrhea.^[Ref]

Hematologic

Hematologic side effects have included anemia.^[Ref]

Nervous system

Nervous system side effects have included headache, paresthesia, and dizziness.^[Ref]

Dermatologic

Dermatologic side effects have included rash.^[Ref]

General

General side effects have included taste perversion.^[Ref]

Local

Local side effects have included pain and injection site reactions.^[Ref]

Hypersensitivity

Hypersensitivity side effects have included anaphylactic and anaphylactoid reactions involving cardiovascular, respiratory and/or cutaneous manifestations which ranged from mild to severe. Some patients experienced circulatory collapse and died. In most cases, initial symptoms occurred within minutes of administration and resolved with prompt emergency treatment.